نتایج جستجو برای: bcr

تعداد نتایج: 11052  

Journal: :Haematologica 2010
Michael Koldehoff Lambros Kordelas Dietrich W Beelen Ahmet H Elmaagacli

BACKGROUND Selective inhibition of the BCR-ABL tyrosine kinase by RNA interference has been demonstrated in leukemic cells. We, therefore, evaluated specific BCR-ABL small interfering RNA silencing in BCR-ABL-positive cell lines, including those resistant to imatinib and particularly those with the T315I mutation. DESIGN AND METHODS The factor-independent 32Dp210 BCR-ABL oligoclonal cell line...

Journal: :Clinical advances in hematology & oncology : H&O 2011
Jan A Burger Nicholas Chiorazzi

B cell receptor (BCR) signaling plays an important pathogenic role in chronic lymphocytic leukemia (CLL) and B cell lymphomas, based on structural restrictions of the BCR, and BCR-dependent survival and growth of the malignant B cells. In CLL and lymphoma subtypes, ligand-independent ('tonic') and ligand-dependent BCR signaling have been characterized, which can involve mutations of BCR pathway...

Journal: :Cancer cell 2010
Mark A Gregory Tzu L Phang Paolo Neviani Francesca Alvarez-Calderon Christopher A Eide Thomas O'Hare Vadym Zaberezhnyy Richard T Williams Brian J Druker Danilo Perrotti James Degregori

Although Bcr-Abl kinase inhibitors have proven effective in the treatment of chronic myeloid leukemia (CML), they generally fail to eradicate Bcr-Abl(+) leukemia cells. To identify genes whose inhibition sensitizes Bcr-Abl(+) leukemias to killing by Bcr-Abl inhibitors, we performed an RNAi-based synthetic lethal screen with imatinib mesylate in CML cells. This screen identified numerous compone...

Journal: :Molecular and cellular biology 1995
Y Maru K L Peters D E Afar M Shibuya O N Witte T E Smithgall

The human bcr gene encodes a protein with serine/threonine kinase activity, CDC24/dbl homology, a GAP domain, and an SH2-binding region. However, the precise physiological functions of BCR are unknown. Coexpression of BCR with the cytoplasmic protein-tyrosine kinase encoded by the c-fes proto-oncogene in Sf-9 cells resulted in stable BCR-FES protein complex formation and tyrosine phosphorylatio...

Journal: :Agriculture 2022

Due to its high persistence in soil, oxyfluorfen has negative effects on environmental and human health. To reduce soil contamination impacts non-target organisms, biochar is introduced into soils immobilize sequestrate as a remediation practice. Three types of common China were selected (rice hull, BCR) was added investigate the desorption bioavailability after aging BCR for 0, 1, 3, 6 months....

Journal: :Vaccine 2010
Melanie R Bui Victoria Hodson Tom King Derek Leopold Shaodong Dai Valerie Fiolkoski Sarah Oakes Richard Duke David Apelian Alex Franzusoff James DeGregori

Chromosomal translocations generating the BCR-ABL oncogene cause chronic myeloid leukemia (CML) and a subset of acute lymphoblastic leukemia. The BCR-ABL(T315I) mutation confers drug resistance to FDA-approved targeted therapeutics imatinib mesylate, dasatinib, and nilotinib. We tested the ability of a recombinant yeast-based vaccine expressing the T315I-mutated BCR-ABL antigen to stimulate an ...

2017
Miao Gao Zheng-Lan Huang Kun Tao Qing Xiao Xin Wang Wei-Xi Cao Min Xu Jing Hu Wen-Li Feng

Aberrant phosphorylation and overexpression of BCR-ABL fusion protein are responsible for the main pathogenesis in chronic myeloid leukemia (CML). Phosphorylated BCR-ABL Y177 recruits GRB2 adaptor and triggers leukemic RAS-MAPK and PI3K-AKT signals. In this study, we engineered a SPOA system to dephosphorylate and degrade BCR-ABL by targeting BCR-ABL Y177. We tested its effect on BCR-ABL phosph...

Journal: :Blood 2010
Ruriko Tanaka Matthew S Squires Shinya Kimura Asumi Yokota Rina Nagao Takahiro Yamauchi Miki Takeuchi Hisayuki Yao Matthias Reule Tomoko Smyth John F Lyons Neil T Thompson Eishi Ashihara Oliver G Ottmann Taira Maekawa

Despite promising clinical results from imatinib mesylate and second-generation ABL tyrosine kinase inhibitors (TKIs) for most BCR-ABL(+) leukemia, BCR-ABL harboring the mutation of threonine 315 to isoleucine (BCR-ABL/T315I) is not targeted by any of these agents. We describe the in vitro and in vivo effects of AT9283 (1-cyclopropyl-3[5-morpholin-4yl methyl-1H-benzomidazol-2-yl]-urea), a poten...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید