introduction: ghrelin is an endogenous peptide that has diverse functions in the body. one of the newly recognized roles of this peptide is its antiapoptotic effect. however, this function has not been investigated in normobaric hypoxia- induced apoptosis in body organs. this study will examine the effect of ghrelin treatment on bax-bcl-2 gene expression in the kidney of chronic hypoxic rats. m...

目的： 检测结直肠腺癌组织及癌旁正常组织bcl-2、 β-catenin蛋白表达，探讨bcl-2、 β-catenin与患者的年 龄、性别、肿瘤部位、分化程度、与、浸润深度、淋巴结转移及TNM分期等临床病理参数的关系。 方法： 原发性结直 肠腺癌及对应的癌旁正常组织各62例用免疫组织化学方法检测bcl-2、 β-catenin蛋白表达情况。结果 结直肠癌组织bcl- 2、 β-catenin蛋白表达高于远切端正常黏膜， bcl-2与浸润深度、淋巴结转移及TNM分期有关（ P < 0.05）； β-catenin与 肿瘤的分化程度、淋巴结转移及TNM分期有关（ 0.05）。 结论： 结直肠腺癌组织bcl-2和β-catenin在结直肠癌组织 中高表达，且存在一定的相关性。

Alternatif tıpta kemoterapi benzeri tedavi yöntemlerine ek olarak sıklıkla bitkisel kökenli doğal ilaçlar kullanılmaktadır. Panax ginseng bunlardan biridir ve sinir sistemi kaynaklı hastalıklarda tercih edilmektedir. Çalışmamızda amaç, sisplatinden önce kullanılan ginsengin YKG1 glioblastoma hücrelerinde hücre ölümü canlılığı bakımından değerlendirilmesidir. Ticari satın alınan hücreleri, % 5 C...

Back ground: Although the cell differentiation is an inseparable part of development in multicellular organisms, the regulating molecular pathway of it still is not fully defined. In the other hand, apoptosis is a fundamental physiological process which plays an essential role in a variety of biological events during development. Moreover, recent studies have found that apoptosis shows several ...

Apoptosis, programmed cell death, has a central role in developmental biology and maintaining the equilibrium of renewing tissues. A founding member Bcl-2 family regulatory proteins for apoptosis is Bcl-2, which encoded by BCL2 gene. Caspase-3 shares typical features with all caspases, including acting as crucial mediator apoptosis.

  Background and Objectives: Apoptosis of eosinophils is of significant value in assessing the airway inflammation in patients with asthma. Our purpose was to investigate the degree of expression of the Bcl-2 protein in sputum eosinophils during acute asthma exacerbation and its relationship with exacerbation severity.    Materials and Methods: The study was carried out in Mostafa Khomeini Ho...