malignancies of the midface result in cosmetic deformities that make maxillofacial prosthesis as an integral part of the treatment plan. facial defects can be devastating in their impact on physical structure and function of the affected individual, leading to potentional compromises in quality of life. reconstruction of nasal defects is a challenge for the prosthodontist because of esthetic an...

objective: basal cell carcinoma (bcc) is the most common human malignant neoplasm which is more frequent in white individuals. ptch and p53 are two major tumor suppressor genes which play important roles in pathogenesis of bcc. ptch is a twelve-pass transmembrane protein. it is an essential component of the sonic hedgehog signaling pathway that plays as a receiving receptor for members of the h...

background: in addition to the well-defined histological criteria for squamous cell carcinoma (scc) and basal cell carcinoma (bcc), immunohistochemical techniques can be used in difficult cases for their differentiation. as differential diagnosis between trichoepithelioma (te) and bcc is sometimes difficult for the clinician and the pathologist, cd10 may be a useful marker for definite diagnosi...

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the most frequently mutated tumor suppressor gene found in human cancer is p53. in a normal situation, p53 is activated upon the induction of dna damage to either arrest the cell cycle or else induce apoptosis. however, when mutated, p53 is no longer able to properly accomplish these functions. our aim was to investigate p53 protein alteration in cases of basal cell carcinoma (bcc) and compare ...

Background: Basal cell carcinoma (BCC) is the most common skin cancer in whites. Objective: Determination of anatomical localization of BCC in relation to histological subtypes of this tumor. Patients and methods: This survey is a descriptive cross sectional study carried out on 189 cases of BCC patients diagnosed in Hamadan Sina hospital between 1997-1999. Results: This study showed 7 hi...