Baclofen is used to manage alcohol dependence. This study describes a simple method using liquid chromatography coupled to high-resolution mass spectrometry (LC-HR-MS) developed in plasma samples. This method was optimized to allow quantification of baclofen and determination of metabolic ratio of its metabolites, an oxidative deaminated metabolite of baclofen (M1) and its glucuronide form (M2)...

One important function of GABA B receptors is the control neuronal activity to prevent overexcitation and thereby excitotoxic death, which a hallmark cerebral ischemia. Consequently, sustained activation with selective agonist baclofen provides neuroprotection in vitro vivo models However, conditions severely downregulate receptors, would compromise neuroprotective effectiveness baclofen. On ot...

BACKGROUND The results of preclinical studies suggest that baclofen may be useful in the treatment of stroke patients with persistent hiccups. This study was aimed to assess the possible efficacy of baclofen for the treatment of persistent hiccups after stroke. METHODS In total, 30 stroke patients with persistent hiccups were randomly assigned to receive baclofen (n = 15) or a placebo (n = 15...

Inhibition mediated by GABA-B receptors can play a role in epilepsy. We therefore studied its involvement in cortical epileptic afterdischarges in adult rats by means of a GABA-B receptor agonist baclofen. Three different experiments were performed with cortical epileptic afterdischarges and an additional experiment studied possible effect of baclofen on cortical interhemispheric (transcallosal...

I wish to propose a hypothesis that could help explain some of the effects of baclofen in alcohol dependence that are described in Dr. Bucknam’s case study (Bucknam, 2007) and in my self-case report (Ameisen, 2005). At a behavioural level, alcohol, baclofen and GHB all share sedative/hypnotic effects in humans. Clinical trials have shown baclofen to reduce anxiety in alcoholic (Krupitsky et al ...

Baclofen became popular when cardiologist Olivier Ameisen described complete and prolonged suppression of symptoms and consequences of alcohol-dependence upon the use of high-dose baclofen in a self-case report (Ameisen 2005). In 2012, baclofen was approved by the AFSSAPS (Agence française de sécurité sanitaire des produits de santé French Agency for the Safety of Health Products) for use in th...

BACKGROUND Baclofen, the agonist of GABA(B) receptors, influences hypoxia-induced deficits in learning and memory processes. METHODS We studied the effects of baclofen on acquisition in the passive avoidance test and in the Morris water maze in groups of rats without or after hypoxia as well as the influence of baclofen on MMP-2 and MMP-9 levels in the hippocampus. RESULTS Even though baclo...

Inhibition mediated by GABA-B receptors can play a role in epilepsy. We therefore studied its involvement in cortical epileptic afterdischarges in adult rats by means of a GABA-B receptor agonist baclofen. Three different experiments were performed with cortical epileptic afterdischarges and an additional experiment studied possible effect of baclofen on cortical interhemispheric (transcallosal...

Background and aims: Transient lower oesophageal sphincter relaxations (TLOSRs) are the major cause of gastro-oesophageal reflux in normal subjects and in most patients with reflux disease. The gamma aminobutyric acid (GABA) receptor type B agonist, baclofen, is a potent inhibitor of TLOSRs in normal subjects. The aim of this study was to investigate the effect of baclofen on TLOSRs and postpra...