Bladder cancer is an important health problem worldwide due to high prevalence rates and costs related to treatment. A reduction in recurrence rates has been observed since the introduction of adjuvant intravesical immunotherapy with bacillus Calmette-Guerin. There are mild complications that are easily solved by local measures and orientations. Bladder contracture, a rare and severe local comp...

Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that primarily infects cattle but has wide range of hosts. It represents global health problem affecting the livestock industry tremendously, with economic losses about 3 billion annually. Dairy produce decline 10% in terms liters milk produced and 5% meat because live weight loss seized carcasses abattoirs. The core ...

Bacillus Calmette-Guerin (BCG) vaccination has been reported to protect neonates from non-tuberculous pathogens, but no biological mechanism to explain such effects is known. We hypothesised that BCG produces broad-spectrum anti-microbial protection via a hepcidin-mediated hypoferraemia, limiting iron availability for pathogens. To test this we conducted a trial in 120 Gambian neonates comparin...

Tuberculosis remains the most common cause of death due to a single infective organism. Despite the availability of a vaccine and chemotherapeutic options, the global disease burden remains relatively unaffected. The ability of the mycobacterial etiological agents to adopt a semidormant, phenotypically drug-resistant state requires that chemotherapy is both complex and lengthy. The emergence of...

A number of mainly observational studies suggest that many African females below the age of one year die each year from the nonspecific effects of vaccination with diphtheria-tetanus toxoids and killed (whole-cell) Bordetella pertussis (DTwP). In contrast, similar studies suggest that many African females and males may have their lives saved each year by the nonspecific immunological benefits o...

conclusions post immunization lv is a rare complication of the bcg vaccine and should be considered by any physician. lupus vulgaris is a paucibacillary form of tb. therefore, acid fast bacilli are not detected in most cases. the pcr is a useful method for confirmation of the diagnosis of lv. introduction lupus vulgaris (lv) is one type of cutaneous tuberculosis (tb) but a rare complication of ...

Tuberculosis affects nine million individuals and kills almost two million people every year. The only vaccine available, Bacillus Calmette-Guerin (BCG), has been used since its inception in 1921. Although BCG induces host-protective T helper 1 (Th1) cell immune responses, which play a central role in host protection, its efficacy is unsatisfactory, suggesting that additional methods to enhance...

background bcg (bacille calmette-guerin) vaccine is an attenuated live vaccine administered to prevent tuberculosis. disseminated infection due to bcg is a rare life threatening complication of this vaccine, especially in immunocompromised patients. objectives the current study evaluated the sensitivity pattern of the bcg strain supplied by the institute de pasteur, iran against anti-mycobacter...

12 Affiliations: 13 14 Vandana Singh 15 Senior Project Fellow 16 Division of Microbiology 17 CSIR-Central Drug research Institute 18 Lucknow, 226031, INDIA, E. mail: [email protected] 19 20 Rajesh Kumar Biswas 21 Senior Research Fellow 22 Division of Microbiology 23 CSIR-Central Drug research Institute 24 Lucknow, 226031, INDIA, E. mail: [email protected] 25 26 27 28 29 Corresponden...