نتایج جستجو برای: b5

تعداد نتایج: 2878  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Zhaochun Chen Patricia Earl Jeffrey Americo Inger Damon Scott K Smith Yi-Hua Zhou Fujuan Yu Andrew Sebrell Suzanne Emerson Gary Cohen Roselyn J Eisenberg Juraj Svitel Peter Schuck William Satterfield Bernard Moss Robert Purcell

Chimpanzee Fabs against the B5 envelope glycoprotein of vaccinia virus were isolated and converted into complete mAbs with human gamma 1 heavy chain constant regions. The two mAbs (8AH8AL and 8AH7AL) displayed high binding affinities to B5 (Kd of 0.2 and 0.7 nM). The mAb 8AH8AL inhibited the spread of vaccinia virus as well as variola virus (the causative agent of smallpox) in vitro, protected ...

2010
Natalia Cheshenko Janie B. Trepanier Theodore J. Segarra A. Oveta Fuller Betsy C. Herold

Prevention of genital herpes is a global health priority. B5, a recently identified ubiquitous human protein, was proposed as a candidate HSV entry receptor. The current studies explored its role in HSV infection. Viral plaque formation was reduced by approximately 90% in human cells transfected with small interfering RNA targeting B5 or nectin-1, an established entry receptor. However, the mec...

2016
Varun Sondhi Bryn M. Owen Jiayan Liu Robert Chomic Steven A. Kliewer Beverly A. Hughes Wiebke Arlt David J. Mangelsdorf Richard J. Auchus

Androgen and estrogen biosynthesis in mammals requires the 17,20-lyase activity of cytochrome P450 17A1 (steroid 17-hydroxylase/17,20-lyase). Maximal 17,20-lyase activity in vitro requires the presence of cytochrome b5 (b5), and rare cases of b5 deficiency in human beings causes isolated 17,20-lyase deficiency. To study the consequences of conditional b5 removal from testicular Leydig cells in ...

Journal: :American journal of clinical pathology 2005
Lian A Bonds Pat Barnes Kathryn Foucar Cordelia E Sever

B5 fixation achieves superior morphologic detail. However, environmental concerns have led to labor-intensive and costly requirements for disposal of mercury-containing fixatives. We performed a blinded prospective study to find a safe, mercury-free alternative to B5. Morphology was evaluated with 6 fixatives, including B5, in a blinded fashion. Acetic acid-zinc-formalin (AZF) was selected for ...

2014
Adam P. Kardon Erika Polgár Junichi Hachisuka Lindsey M. Snyder Darren Cameron Sinead Savage Xiaoyun Cai Sergei Karnup Christopher R. Fan Gregory M. Hemenway Carcha S. Bernard Erica S. Schwartz Hiroshi Nagase Christoph Schwarzer Masahiko Watanabe Takahiro Furuta Takeshi Kaneko H. Richard Koerber Andrew J. Todd Sarah E. Ross

Menthol and other counterstimuli relieve itch, resulting in an antipruritic state that persists for minutes to hours. However, the neural basis for this effect is unclear, and the underlying neuromodulatory mechanisms are unknown. Previous studies revealed that Bhlhb5(-/-) mice, which lack a specific population of spinal inhibitory interneurons (B5-I neurons), develop pathological itch. Here we...

2005
Takeshi Kitao Yoshiki Sugita Yoshimasa Yoneyama Kenichi Hattori

Two NADH diaphorases, diaphorase I and II, were isolated from normal red cells and congenital methemoglobinemic red cells by CM-cellulose and DE 32 column chromatography. For methemoglobinemic sample, activities of diaphorase I and diaphorase II were 80% and less than 5% of those for the normal red cells, respectively. Only diaphorase II showed cytochrome b5 reductase activity. The cytochrome b...

Journal: :Journal of virology 2008
Beatriz Perdiguero María M Lorenzo Rafael Blasco

The outer envelope of the extracellular form of vaccinia virus contains five virus-encoded proteins, F13, A33, A34, A56, and B5, that, with the exception of A56, are implicated in virus egress or infectivity. A34, a type II transmembrane glycoprotein, is involved in the induction of actin tails, the release of enveloped virus from the surfaces of infected cells, and the disruption of the virus ...

2015
Shu-Ting Luo Pai-Shan Chiang Wan-Yu Chung Min-Yuan Chia Kuo-Chien Tsao Ying-Hsiang Wang Tzou-Yien Lin Min-Shi Lee

BACKGROUND Enterovirus 71 (EV71) belongs to picornavirus family and could be classified phylogenetically into three major genogroups (A, B and C) including 11 genotypes (A, B1-B5 and C1-C5). Since 1997, EV71 has caused large-scale of epidemics with neurological complications in Asian children. In Taiwan, nationwide EV71 epidemics with different predominant genotypes have occurred cyclically sin...

2004
Hervé Guillou Sabine D’Andrea Vincent Rioux Romain Barnouin Stéphanie Dalaine Frédérique Pedrono Sophie Jan Philippe Legrand

The 6-desaturase catalyzes key steps in longchain polyunsaturated fatty acid biosynthesis. Although the gene coding for this enzyme has been isolated in diverse animal species, the protein structure remains poorly characterized. In this work, rat 6-desaturase expressed in COS-7 cells was shown to localize in the endoplasmic reticulum. As the enzyme contains an N-terminal cytochrome b5-like doma...

2017
Marie Stiborová Radek Indra Eva Frei Kateřina Kopečková Heinz H. Schmeiser Tomáš Eckschlager Vojtěch Adam Zbyněk Heger Volker M. Arlt Václav Martínek

Abstract Ellipticine is an anticancer agent that forms covalent DNA adducts after enzymatic activation by cytochrome P450 (CYP) enzymes, mainly by CYP3A4. This process is one of the most important ellipticine DNA-damaging mechanisms for its antitumor action. Here, we investigated the efficiencies of human hepatic microsomes and human recombinant CYP3A4 expressed with its reductase, NADPH:CYP ox...

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