Type 2 bradykinin (B2)-receptor antagonists have been used to define the role of endogenous kinin peptides. However, interpretation of the effects of B2-receptor antagonists has been limited by lack of information concerning the effects of these antagonists on endogenous kinin and angiotensin peptide levels. If kinin levels were subject to short-loop-feedback regulation mediated through B2 rece...

We prove that the sumset {p2+b2+2n : p is prime and b, n ∈ N} has positive lower density. We also construct a residue class with an odd modulus that contains no integer of the form p2 + b2 + 2n. Similar results are established for the sumset {b1 + b2 + 2n 2 : b1, b2, n ∈ N}.

OBJECTIVE Ephrin-B2 plays a key role in vascular development. The purpose of this study was to elucidate the molecular mechanisms of ephrin-B2 signaling through the EphB receptor in endothelial cells and to determine whether ephrin-B2 contributes to in vivo angiogenesis in adult mice. METHODS AND RESULTS A chemotaxis assay on a polycarbonate membrane revealed that ephrin-B2/Fc chimeric protei...

The B2 antigen characterized by means of a monoclonal antibody (14) is a 140,000 Mr protein expressed only in certain stages of the differentiation of lymphocytes of the B lineage. Here we examine the relationship between B2 and the membrane complement receptor type 2 (CR2) for the complement fragment C3d (11, 12), which is also associated only with B cells. Both phenotypic markers are distribu...

Both bradykinin B2 and angiotensin II type 2 (AT2) receptors are known to stimulate renal production of nitric oxide (NO). To evaluate the individual contributions of AT2 and B2 receptors to renal NO production, we monitored renal interstitial, stable NO metabolites and cGMP by a microdialysis technique in conscious, bradykinin B2-null and wild-type mice (n=8 in each group) during low sodium in...

Bone metastasis is one of the predominant causes of cancer lethality. This study demonstrates for the first time how b2-microglobulin (b2-M) supports lethal metastasis in vivo in human prostate, breast, lung, and renal cancer cells. b2-M mediates this process by activating epithelial to mesenchymal transition (EMT) to promote lethal bone and soft tissue metastases in host mice. b2-M interacts w...

The effect of dietary riboflavin (B2) supplementation and selenium (Se) source on the performance and Se metabolism of weanling pigs was studied. Pigs fed a B2-supplemented (10 mg/kg) casein-glucose diet for 18 d gained faster than pigs fed the B2-unsupplemented diet. Percentage active erythrocyte glutathione reductase (GR) declined rapidly when pigs were placed on the B2-unsupplemented diet an...

It is well-known that B2 is an inverse 0-simple semigroup that has played a distinguished role in the theory of semigroups. Let B2 be the variety generated by B2, and let B0 be the variety generated by the subsemigroup B0 = {0, d, cd, dc} of B2. Since all semigroups with five or fewer elements are finitely based [5], the variety B2 and its subvariety B0 are finitely based. In fact, it has been ...

6,980,697 B1 * 12/2005 Basso et al .................... 382/274 7,171,023 B2 1/2007 Kim et al. 7,177,446 B2 * 2/2007 Magarey ....................... 382/103 7,403,652 B2 7/2008 Boncyk et al. 7,940,956 B2 * 5/2011 Kinoshita et al .............. 382/103 7,957,557 B2 * 6/2011 Otsu et al ...................... 382/103 7,996,409 B2 * 8/2011 Hsu et al ....................... 707/748 8,170,280 B2 * 5/...

PURPOSE Cyclin B2, a G(2)-M cyclin, is overexpressed in colorectal adenocarcinomas compared with the normal mucosa. This study examined the level of cyclin B2 overexpression according to the histologic findings and investigated the mechanism(s) and clinical implications of cyclin B2 overexpression in colorectal adenocarcinomas. EXPERIMENTAL DESIGN The immunoreactivity of the polyclonal antibo...