نتایج جستجو برای: azd1152
تعداد نتایج: 42 فیلتر نتایج به سال:
BACKGROUND In this phase 2 study, the authors evaluated the efficacy, safety, and tolerability of the Aurora B kinase inhibitor barasertib compared with low-dose cytosine arabinoside (LDAC) in patients aged ≥ 60 years with acute myeloid leukemia (AML). METHODS Patients were randomized 2:1 to receive either open-label barasertib 1200 mg (as a 7-day intravenous infusion) or LDAC 20 mg (subcutan...
https://doi.org/10.1016/j.ebiom.2017.10.026 2352-3964/© 2017 The Author(s). Published by Elsevier B Several mitotic proteins, whose expression or function has been found deregulated in human solid neoplasms, are thought to play a critical role in tumor genetic instability, a hallmark of cancer (Hanahan and Weinberg, 2011; Otto and Sicinski, 2017). These include the three serine/threonine Aurora...
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