this experimental study was carried out to induce a co-infection of h9 aiv and ibv with inoculumsprepared from tracheal scrubbed epithelium tissues in natural co-infected birds to rule out the effect of fieldundesired environmental conditions and also other infectious causative agents. eighty 1-day-old broilerswere randomly divided into four equal groups. at 21 days of age, three test groups we...

background: the h9n2 subtype of avian influenzaviruses (aivs) has been isolated in multiple avian species inmany european, asian, african and american countries. sincethe first outbreak of h9n2 virus in iran in 1998, this virus haswidely circulated throughout the country, resulting in majoreconomic losses in chicken flocks. several amino acids in thevirus ribonucleoprotein (rnp) complex includi...

H7N3 and H7N7 are highly pathogenic avian influenza (HPAI) viruses and have posed a great threat not only for the poultry industry but for the human health as well. H7N9, a low pathogenic avian influenza (LPAI) virus, is also highly pathogenic to humans, and there is a great concern that these H7 subtypes would acquire the ability to spread efficiently between humans, thereby becoming a pandemi...

BACKGROUND Although H5N1 avian influenza viruses pose the most obvious imminent pandemic threat, there have been several recent zoonotic incidents involving transmission of H7 viruses to humans. Vaccines are the primary public health defense against pandemics, but reliance on embryonated chickens eggs to propagate vaccine and logistic problems posed by the use of new technology may slow our abi...

Influenza A virus (IAV) causes central nervous system (CNS) lesions in avian and mammalian species, including humans. However, the mechanism used by IAV to invade the brain has not been determined. In the current work, we used chickens infected with a highly pathogenic avian influenza (HPAI) virus as a model to elucidate the mechanism of entry of IAV into the brain. The permeability of the BBB ...

Emerging H7N9 influenza virus infections in Asia have once more spurred the development of effective prepandemic H7 vaccines. However, many vaccines based on avian influenza viruses--including H7--are poorly immunogenic, as measured by traditional correlates of protection. Here we reevaluated sera from an H7N1 human vaccine trial performed in 2006. We examined cross-reactive antibody responses ...

avian influenza is one of the most important diseases in avian industry, which also threats human population. thus, vaccination is necessary for controlling this viral disease. in this study, killed vaccine of avian influenza subtype h9n2 and formalin solution (for virus inactivation) were used. it is necessary to study the effect of different factors such as formalin concentration, as well as ...

although migratory waterfowl is well known to be a major reservoir for avian influenza virus (aiv), there are only few recently published reports about the seroprevalence of aiv in this group of birds. to investigate the aiv antibody status in migratory waterfowl of iran, we collected 217 serum samples from 25 different species of waterfowl during 2003 and 2004. these serum samples were tested ...

influenza is a contagious viral disease that is seen in avian, human and other mammals, so its control is important. vaccination against influenza virus subtype h9n2 is one of the ways in controlling program, for this reason several vaccines has been produced. recently, application of inactivated oil-emulsion vaccines in poultry for controlling low pathogenic avian influenza is increasing. at p...

influenza Avirus subtype H7N1 antigen to find out its relatedness by means of the HI assay. The H7 antigen reacted with WHO reference antibodies to high titers (HI titer, 320), indicating antigenic similarity with influenza A(H7N9) isolated from China. This revealed the appropriateness of using the H7 virus antigen in the study. All serum samples from the high-risk group and the general populat...