The US Food and Drug Administration (FDA) has recently suggested that the bioequivalence (BE) for products of drugs with narrow therapeutic indices (NTI) be assessed by the approach of reference-scaled average BE (SABE). Subsequently, in December, 2012, the FDA issued draft guidances for the comparison of products of warfarin sodium and of tacrolimus. The guidances expect that 4-period studies ...

For the OLS estimators in a classical linear model to have average partial effects interpretation, one usually imposes the so-called “strict exogeneity”condition. In practice, testing strict exogeneity condition can be done by omnibus nonparametric test. However, there are cases where strict exogeneity condition fails but the average partial effects interpretation of OLS estimator still survive...

BACKGROUND Little is known about the effects of chemotherapy on cognitive function. The purposes of this metaanalysis were to estimate the effect sizes for the effect of chemotherapy on each domain of cognitive function and to differentiate effect sizes by each method of comparison of effects (i.e., normative data, control group, or baseline data). METHODS Sixteen studies that evaluated cogni...

In this study, a comparison of features for discriminating between different music performers playing the same piece is presented. Based on a series of statistical experiments on a data set of piano pieces played by 22 performers, it is shown that the deviation from the performance norm (average performance) is better able to reveal the performers’ individualities in comparison to the deviation...

The performance of Construction Management (CM) students in their undergraduate studies is believed to be dependent on their mathematics and physics performance. The overall performance of students is measured by their overall Grade Point Average (GPA) for this study. Similarly, the performance of students in mathematics and physics are measured by the respective GPAs in these subjects. This st...