4-[F]Fluoroiodobenzene ([F]FIB) is a versatile building block in F radiochemistry used in various transition metalmediated C–C and C–N cross-coupling reactions and [F]fluoroarylation reactions. Various synthesis routes have been described for the preparation of [F]FIB. However, to date, no automated synthesis of [F]FIB has been reported to allow access to larger amounts of [F]FIB in high radioc...

This paper presents a formal speciication and a proof of correctness for the register optimization task in high{level synthesis. A widely implemented register optimization algorithm is modeled in higher{order logic and veriied in a theorem prover environment. A rich collection of correctness properties is systematically formulated during the theorem proving exercise. These properties constitute...

It is shown that theorem proving methods can lead to program synthesis and algorithm implementation by using pairs of logic laws: a deductive law for proving the theorem and a constructive law for synthesizing the program or algorithm. The construction of program schemata in an algorithmic programming environment and logic programming in a declarative programming environment appear as two parti...

Small-molecule synthesis usually relies on procedures that are highly customized for each target. A broadly applicable automated process could greatly increase the accessibility of this class of compounds to enable investigations of their practical potential. Here we report the synthesis of 14 distinct classes of small molecules using the same fully automated process. This was achieved by strat...

We extend an earlier motion-synthesis algorithm for physically realistic articulated figures in several ways. First, we summarize several incremental improvements to the original algorithm that improve its efficiency significantly and provide the user with some ability to influence what motions are generated. These techniques can be used by an animator to achieve a desired movement style, or th...

Synthesis is a particularly challenging problem for concurrent programs. At the same time it is a very promising approach, since concurrent programs are difficult to get right, or to analyze with traditional verification techniques. This paper gives an introduction to distributed synthesis in the setting of Mazurkiewicz traces, and its applications to decentralized runtime monitoring.

DATA SYNTHESIS This study presents a review of several automated dispensing technologies that could be used in a hospital, managed care, or long-term care setting. Smaller automated systems reviewed are the Argus, Automated 250FD, Automated Pharmacy Station, Baxter ATC-212, Baxter ATC 240, Medserv, Pyxis Medstation, Medstation Rx, and Selectrac-Rx. Larger automated systems reviewed are the Bake...

Normative systems (norms) have been widely proposed as a technique for coordinating multi-agent systems. The automated synthesis of norms for coordination remains an open and complex problem, which we tackle in this paper. We propose a novel mechanism called IRON (Intelligent Robust On-line Norm synthesis mechanism), for the on-line synthesis of norms. IRON aims to synthesise conflict-free norm...

The rapid layout synthesis of a microresonator from high-level functional specifications and design constraints is demonstrated. Functional parameters such as resonant frequency, quality factor, and displacement amplitude at resonance are satisfied while simultaneously minimizing an objective function. The optimal synthesis tool allows exploration of micromechanical design issues and objectives...

This paper presents a method for synthesising sound and complete tableau calculi. Given a specification of the formal semantics of a logic, the method generates a set of tableau inference rules that can then be used to reason within the logic. The method guarantees that the generated rules form a calculus which is sound and constructively complete. If the logic can be shown to admit finite filt...