The feasibility and efficacy of high-dose melphalan followed by autologous hematopoietic stem cell transplantation in newly diagnosed elderly patients with multiple myeloma was analyzed prospectively. Fifty-six multiple myeloma patients, aged 65 years or over, from 6 French centers were studied. The induction therapy was bortezomib-based in combination with dexamethasone and either thalidomide,...

background: it is suggested that ha-1 mismatching among hematopoietic stem cell transplanted recipients-donors is associated with acute graft-versus-host disease (agvhd). so the aim of this study was to evaluate ha-1 frequency and examine the correlation between ha-1 disparity and gvhd patients who received transplantation from a hla-identical sibling. samples and methods: the dna was extracted...

background: vancomycin is used abundantly in patients undergoing hsct, especially during neutropenic fever. despite its widespread use little is known about vancomycin pharmacokinetics in hsct patients. we conducted this study to investigate vancomycin pharmacokinetic parameters in our hsct patients and to evaluate current dosing regimen based on trough vancomycin concentrations measurement. me...

abstract background hemorrhagic cystitis(hc)is one of the most challenging complications in hematopoietic stem cell transplantation(hsct). estrogen is one of the suggested treatments for controllingthis problem. material and methods we performed a randomizedcase - controlled study to evaluate the efficacy of oral conjugated estrogen on hc management in 56hsct patients.patients were randomly ass...

allogeneic hematopoietic stem cell transplantation is used in the treatment of patients suffering from hematologic and non-hematologic disorders, but the application is limited by the identification of a suitable donor. umbilical cord blood (ucb) is an alternative source of hematopoietic stem cell (hsc) transplantation. despite all advantages, the limited cell dose is one of the  major obstacle...

Pancreatoblastoma is a rare tumor and surgery with complete resection is the main treatment approach. Prognosis for patients with residual disease after surgery is usually dismal. A 14-year-old girl with pancreatoblastoma in the pancreatic body and tail was submitted to preoperative chemotherapy. She underwent surgery and the tumor was resected with microscopic margins. Postoperative chemothera...

When caring for patients with multiple myeloma, questions often arise about the role and timing of autologous hematopoietic stem cell transplantation. As a complement to the other articles in this supplement, as well as to ensure that readers are provided with the insight needed to feel comfortable speaking to patients and other practitioners about this topic, the authors address eight frequent...

stem cell-based therapies have recently opened up new horizons for treatment of various types of diseases including diabetes mellitus. however, long-term efficacy and safety of these novel modalities still remain a serious question. hereby, we aim to report the one-year follow-up results in the diabetic patients who underwent fetal liver-derived hematopoietic stem cell allotransplantation. fift...

introduction: autologous stem cells have greatly influenced the treatment of a variety of malignancies including hodgkin/non-hodgkins lymphoma and acute leukemias. this is a preliminary study comparing the time of engraftment, mortality rate and cost of treatment in outpatient versus inpatient autologous stem cell transplantation (sct) in iran. patients and methods: 11 outpatients (6 hodgkin ly...