Tissue engineering is an increasingly popular method of addressing pathological disorders of cartilage. Recent studies have demonstrated its clinical efficacy, but there is little information on the structural organisation and biochemical composition of the repair tissue and its relation to the adjacent normal tissue. We therefore analysed by polarised light microscopy and immunohistochemistry ...

INTRODUCTION: Autologous chondrocyte transplantation (ACT) is a routine technique to regenerate cartilage tissue in chondral lesions [1]. Instead of using periosteal patch, the method can be enhanced by seeding the cultureexpanded chondrocytes into a biodegradable 3-dimensional scaffold (matrix-associated ACT). These new generation ACT techniques lead to less surgical time, morbidity, and aboli...

OBJECTIVES The lack of effective treatment for cartilage defects has prompted investigations using tissue engineering techniques for their regeneration and repair. The success of tissue-engineered repair of cartilage may depend on the rapid and efficient adhesion of transplanted cells to a scaffold. Our aim in this study was to repair full-thickness defects in articular cartilage in the weight-...

OBJECTIVE To compare the reabsorption characteristics of fresh septal cartilage autografts, preserved homografts, and preserved autografts in the nasal dorsum of rabbits. METHODS Rabbit nasal dorsum cartilage grafts were placed in 3 groups. The first group used fresh autologous cartilage; the second group, alcohol-preserved homologous cartilage; and the third group, alcohol-preserved autologo...

Articular cartilage is characterized by the lack of blood vessels and has a poor self-healing potential. Limited cell numbers and dedifferentiation of chondrocytes when expanded in vitro are the major obstacles of autologous chondrocyte implantation. Autologous chondrocyte implantation is a cell-based treatment that can be used as a second-line measure to regenerate chondral or osteochondral de...

Introduction: Laryngotracheal stenosis can be caused after traumatic injuries to the neck from the subglottic larynx to the trachea. Patients with laryngotracheal stenosis often need a tracheotomy and occasionally may become tracheotomy dependent. Different procedures have been described for the management of these lesions. Management options include techniques of endoscopic dilation, laser res...

Introduction. Microtia presents a congenital ear deformity ranging from minor and barely visible defect to complete absence of the ear. Currently, there are three options for reconstruction: autologous costal cartilage, silicon prothesis prosthetic Ear reconstruction with cartilage is usually performed in two stages. During first stage cartilaginous framework fabricated placed under skin, anato...