Neonatal alloimmune thrombocytopenia should be suspected in any thrombocytopenic infant born to a healthy non-thrombocytopenic mother. Nevertheless, the condition occurs in only 1 or 2/10 000 births.' More often transient neonatal immune thrombocytopenia results from maternal idiopathic thrombocytopenic purpura. We report the coexistence of alloimmunisation and autoimmunisation against platelet...

Immunodeficiency and autoimmune disease may occur concomitantly in the same individual. Some of the immunodeficiency syndromes, especially humoral defects are associated with autoimmune disorders. Hematological manifestations such as thrombocytopenia and hemolytic anemia are the most common presentations. Persistent antigen stimulation due to an inherent defect in the ability of the immune syst...

A 56-year-old Japanese female simultaneously developed thrombocytopenia, sicca symptoms, and an elevation of transaminase. Antiphospholipid antibodies were detected in her serum. The presence of anti-SS-A antibodies in the serum and sialectasis, disclosed by sialography, suggested the presence of primary Sjogren's syndrome (SjS). The laboratory data and the biopsy of the liver showed compatible...

OBJECTIVE To describe the management of prenatal care and delivery in patients bearing autoimmune hepatitis associated with moderate or severe thrombocytopenia. METHODS This study was performed in a tertiary level university hospital. Thirteen pregnancies in ten patients diagnosed with autoimmune hepatitis, complicated by thrombocytopenia, were retrospectively analyzed. The inclusion criteria...

Clopidogrel in combination with aspirin is commonly used for the prevention of thrombosis in patients with coronary artery stents [1]. moreover, since being introduced clopidogrel has proven to be very safe, tolerable, and efficacious [2]. Indications for clopidogrel use are expanding, and include reduction of such cardiovascular events as myocardial infarction and stroke in appropriate patient...

Thrombocytopenia is one of the most common hematologic disorders, characterized by an abnormally low number of platelets from multiple causes. The normal count of thrombocytes (platelets) is between 150,000 and 450,000 per microliter. The clinical expression of thrombocytopenia has broad variation from asymptomatic to life-threatening bleeding. Various syndromes and diseases are associated with...

Serum IgG or, predominantly, IgM antibody binding to electrophoretically separated normal platelet membrane protein antigens were detected by immunoblotting in five children with thrombocytopenia associated with varicella. Glycoproteins GPIb, GPIIb, GPIIIa, and other 25-260 kilodalton (kDa) proteins were identified as target antigens, suggesting a transient autoimmune mechanism causing the thro...

Primary immune thrombocytopenia (ITP) is the most common cause of thrombocytopenia in children and adolescents and can be considered as a paradigmatic model of autoimmune disease. This second part of our review describes the clinical presentation of ITP, the diagnostic approach and overviews the current therapeutic strategies. Interestingly, it suggests an algorithm useful for differential diag...