The centrosomal kinase Aurora A (AurA) is required for cell cycle progression, centrosome maturation and spindle assembly. However, the way it participates in spindle assembly is still quite unclear. Using the Xenopus egg extract system, we have dissected the role of AurA in the different microtubule (MT) assembly pathways involved in spindle formation. We developed a new tool based on the acti...

BACKGROUND AND PURPOSE Five single-nucleotide polymorphisms (SNPs) (rs4379368, rs10504861, rs10915437, rs12134493 and rs13208321) were recently identified in a Western population with migraine. These migraine-associated SNPs have not been evaluated in a Han Chinese population. This study investigated the associations of specific SNPs with migraine in a Han population. METHODS This was a case-...

Drawing on George Bornstein’s idea of a “textual aura”, this essay proposes distinct instantiation effect arising from the particular circumstances periodical publication and reception, magazine aura. Jean Toomer’s publications in range modernist magazines illustrate manifestations aura, with attention to appearances Broom The Little Review.

Abstract We explain recent popularity in vinyl records by reframing Walter Benjamin’s notion of ‘aura’ terms social forces such as alienation and cultural capital. Where he pays attention to specific artefacts’ mechanical reproducibility a way assessing their aura, we consider how mediums themselves broadly possess variable levels aura inversely related ability be mechanically reproduced consum...

OBJECTIVE To compare the prevalence of an incomplete circle of Willis in patients with migraine with aura, migraine without aura, and control subjects, and correlate circle of Willis variations with alterations in cerebral perfusion. METHODS Migraine with aura, migraine without aura, and control subjects were prospectively enrolled in a 1∶1∶1 ratio. Magnetic resonance angiography was performe...

Aurora kinases possess a conserved catalytic domain (CD) and a N-terminal domain (ND) that varies in size and sequence. We have previously reported that the N-terminal domain of AuroraA (AurA) participates in the localization of the kinase to the centrosome in interphase. AuroraB (AurB) is a chromosome passenger protein and its N-terminal domain is not necessary for its localization or function...

Familial hemiplegic migraine (FHM) is a rare autosomal dominantly inherited subtype of migraine with aura. The clinical characteristics of FHM have been described previously in selected materials or case studies, but population-based studies are important in order to analyse the full spectrum of the disorder. The aim of the present study was to perform a systematic search for familial cases of ...

OBJECTIVE To provide insight into the wide spectrum of migraine during childhood to establish practical and comprehensive treatment strategies. BACKGROUND Although recent studies have confirmed the effect of anti-migraine agents in childhood headaches fulfilling the criteria of migraine without aura, there have been no studies regarding the efficacy of these drugs in childhood migraine withou...

Aura (Jia et al., 2008; Vaughan et al., 2008) is a dependently typed higher-order programming language. It was designed to facilitate the automation of institutional access control policy. Following the Curry-Howard isomorphism, Aura types correspond to logical propositions and its expressions correspond to proofs. At runtime, Aura programs manipulate evidence to construct these authorization p...