Alkene metathesis catalyzed by enantiopure metal alkylidene complexes enables exceptionally versatile strategies to products with configurationally-defined stereocenters. Desymmetrization processes thereby provide reliable stereoselective routes aliphatic structures, while the differentiation of aromatic stereogenic units remained an outstanding challenge. Herein, we describe feasibility alkene...

Abstract Repeated column chromatography using Sephadex LH-20, silica gel (SiO 2 ), and octadecyl SiO (ODS) as well preparative HPLC led to isolation of a new dibenzocyclooctadiene lignan along with four known ones, gomisin L2 ( 1 L1 M1 3 M2 4 ). Their chemical structures were fixed based on MS, IR, NMR data analyses. In addition, the stereochemistry atropisomers, absolute configuration axial ch...