PURPOSE These studies were intended to resolve the conflict between the reasonable inference from the scientific literature that atropine might alter neuromuscular fade and the expectation from informal clinical experience that it does not. METHODS We examined the effect of a high concentration of atropine (20 microM) on moderate neuromuscular block and fade produced by d-tubocurarine (dTC). ...

The study investigated the antidiarrheal potential of methanol extract Combretum dolichopetalum and its solvent fractions. Leaves were extracted using as solvent. This was classified crude (MECD). further fractionated column chromatographic techniques to get various Castor oil used induce diarrhea in animals, following atropine plant extracts confirm any activity. Fecal excretion absorption/sec...

Atropine is an anticholinergic drug, used in treatment of spasm and pain. Postmortem blood atropine concentrations tend to be regionally dependent. We reported in this work the analytical findings of atropine in the peripheral and heart blood from a case of suspected death. Atropine was determined in both peripheral and heart blood by liquid chromatography with tandem mass spectrometry. Towards...

background: cassia italica or senna is a wild plant distributed in south of iran. it increased water consumption and has a laxative effect. in traditional medicine this plant has been used for the dysmenorrheal. objective: in this study we investigated the effect of aqueous extract of cassia italica on uterus contraction. materials and methods: virgin wistar rats 200-300g were purchased. after ...

Introduction: Pesticide poisoning is a serious public health concern all over the world. Alternative therapies for organophosphorus are being explored, and this could be very useful especially in emergency situations of antidote shortages. This study therefore set out to determine effects chlorpheniramine on kidney liver function dichlorvos poisoning. Methodology: Chlorpheniramine (2mg/kg, 4mg/...

a sensitive and fast chemiluminescence (cl) method has been described for the direct determination of atropine. the method is based on the quenching effect of atropine on the cl signals of the luminol– h2o2 reaction catalyzed by hemin in an alkaline medium. hemin could strongly enhance the chemiluminescence of the luminol–h2o2 system. the luminophor of the luminol–h2o2–hemin cl system was ident...

background & aim: a. belladonna (family: solanaceae) is one of important pharmaceutical plants which contain tropane ‎alkaloids. tropane alkaloids are distinct group of secondary metabolites of the ‎solanaceae family.  the most important alkaloids of a. belladonna are atropine and hyoscine that are used extensively because of their medicinal properties. therefore identification and ‎determi...