Conversion of prion protein (PrP(C)) into a pathological isoform (PrP(Sc)) during prion infection occurs in lipid rafts and is dependent on cholesterol. Here, we show that prion infection increases the abundance of cholesterol transporter, ATP-binding cassette transporter type A1 (ATP-binding cassette transporter type A1), but reduces cholesterol efflux from neuronal cells leading to the accumu...

Abstract Tripartite efflux pumps built around ATP-binding cassette (ABC) transporters are membrane protein machineries that perform vectorial export of a large variety drugs and virulence factors from Gram negative bacteria, using ATP-hydrolysis as energy source. Determining the number ATP molecules consumed per transport cycle is essential to understanding efficiency substrate transport. Using...

Hypercholesterolemia is the primary risk factor for cardiovascular disease (CVD). Recent studies reported that stimulation of transintestinal cholesterol excretion (TICE), a nonbiliary excretion, can be strategy preventing CVD. Black elderberry (Sambucus nigra) has been to reduce CVD via its antioxidant, anti-inflammatory, and hypocholesterolemic effects. However, little known about role black ...

Root-synthesized cytokinins regulate the growth, development, and stress responses of aboveground tissues follow transport route via xylem tissue. Arabidopsis ATP-binding cassette (ABC) transporter G family member 14 (AtABCG14) is involved in loading root-synthesized cytokinins. However, phloem unloading cytokinin shoot distribution have remained elusive. The recent study by Zhao et al., (2021)...

Objective: Reverse cholesterol transport, removing excess from peripheral tissues, is an important therapeutic target for atherosclerosis treatment. In this study, we propose a new small molecule, E17241, that may be used to treat by promoting reverse transport via ABCA1 (ATP-binding cassette transporter A1) upregulation. Approach and Results: E17241 (4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-...