BACKGROUND Fc epsilon RI plays a central role in atopy, thus genetic variants of Fc epsilon RI-beta may alter receptor function to enhance atopic responses and may manifest as a more severe atopic phenotype and more symptomatic atopic disease. The immunological and clinical features of atopy in children with and without the Leu 181 variant of Fc epsilon RI-beta were compared. METHODS Sixty Br...

BACKGROUND Obesity is regarded as a potential risk factor for atopy. The aim of this study was to assess the associations of obesity with atopic dermatitis, rhinitis, asthma and food allergy in Chinese adults. METHODS Two hundred and sixty six (266) atopic cases in Harbin, China, were identified according to the current Chinese guidelines for the diagnosis of atopic diseases. All cases had a ...

PURPOSE Atopy is an important cause of asthma. Few data on the prevalence of atopy or comparisons with clinical characteristics of asthma in Korean patients have been published. We evaluated the effects of atopy on clinical profiles and airway inflammation in Korean asthmatics. METHODS We retrospectively enrolled 1,492 asthmatics from the Cohort for Reality and Evolution of Adult Asthma in Ko...

Background: The prevalence of allergic diseases is increasing worldwide. The effective role of omega-3 fatty acids in the maturation of immune system and protection against atopic diseases has been well discussed. However, previous studies revealed conflicting results. This study was conducted to investigate the effect of fish oil consumption by nursing atopic mothers on the level of interferon...

Background and aim: Atopic dermatitis (AD) is a chronic disorder that is most common in early childhood. Both immunological and psychological factors are important in AD pathogenesis and should therefore be taken into account. The aim of this study was to compare behavioral characteristics of 30 infants (3-12 month-old) with AD with 40 controls.Materials and Methods: Th...

BACKGROUND There is little information available about the development of T-cell immunity in healthy and atopic children. We have studied prospectively the mean fluorescence intensity of the T-cell receptor complex-associated CD3, CD4 and CD8 in relation to atopic family history (AFH) and the development of atopic disease. METHODS Children with a defined AFH (n = 172) were followed from birth...

BACKGROUND Atopic dermatitis is a major public health problem, often starting in early childhood and sometimes followed by other allergic diseases. Although hypersensitivity to foods is assumed to play an essential role in the development of atopic dermatitis in some patients, little is known about common food allergens in Iranian children with atopic dermatitis. OBJECTIVES This study was des...

Atopic dermatitis is a common condition in children that is characterized by atopic eczematous skin rash that is highly pruritic. Children with atopic dermatitis might have other immunologic disorders, such as asthma and food allergies. The diagnosis of atopic eczema due to atopic dermatitis in children is a clinical-based one with little value of laboratory investigations. Once the diagnosis i...

Atopic dermatitis is an inflammatory skin disease with early onset and with a lifetime prevalence of approximately 20%. The aetiology of atopic dermatitis is unknown, but the recent discovery of filaggrin mutations holds promise that the progression of atopic dermatitis to asthma in later childhood may be halted. Atopic dermatitis is not always easily manageable and every physician should be fa...

interleukin-4 (il-4) is produced by t-helper cells type 2 (th2) and induces ige synthesis. t-helper cells type 1 (th1) produce interferon-gamma (ifn-gamma) which suppresses th2 and reduces il-4 induced ige production. in this :;tudy , we demonstrated that the levels of specific ige in the serum of atopic children (n=20) were elevated while il-4 production was increased and ifn-gamma secretion w...