Microencapsulation processes of drugs or other functional molecules are of great interest in pharmaceutical production fields. Ultrasonic assisted atomization is a new technique to produce microencapsulated systems by mechanical approach. It seems to offer several advantages (low level of mechanical stress in materials, reduced energy request, reduced apparatuses size) with respect to more conv...

Results of Perdew–Zunger self-interaction corrected (PZ-SIC) density functional theory calculations of the atomization energy of 35 molecules are compared to those of high-level quantum chemistry calculations. While the PBE functional, which is commonly used in calculations of condensed matter, is known to predict on average too high atomization energy (overbinding of the molecules), the applic...

The manufacture of highly drug-loaded fine globular granules eventually applied for orally disintegrating tablets has been investigated using a unique multi-functional rotor processor with acetaminophen, which was used as a model drug substance. Experimental design and statistical analysis were used to evaluate potential relationships between three key operating parameters (i.e., the binder flo...

Multiple regression analysis (MRA) and principal component analysis (PCA) have been used in the present study to examine the relationships between the operational conditions of a unique multi-functional rotor processor, material attributes such as water content during granulation, and a series of associated micromeritics, including the flowability, granule mean size and granule density values. ...

Title of Document: Analysis of the Initial Spray from Canonical Fire Suppression Nozzles Ning Ren, Master of Science, 2007 Directed By: Professor André Marshall, Department of Fire Protection Engineering The performance of a fire suppression spray is governed by injector discharge characteristics. An atomization model based on the theoretical evolution of a radially expanding sheet generated by...

Aim of the present study was to characterize the process of atomization and drying of layer-by-layer emulsions containing lecithin (single layer emulsion) and lecithin/chitosan (multilayer emulsion) and the oxidative stability of the spray-dried emulsions during storage. For this purpose, the analysis of the emulsion spray droplet size during atomization by two different atomization devices, i....

We present a straightforward and rapid surface acoustic wave (SAW) atomization-based technique for encapsulating proteins into 10 mum order particles composed of a biodegradable polymeric excipient, using bovine serum albumin (BSA) as an exemplar. Scans obtained from confocal microscopy provide qualitative proof of encapsulation and show the fluorescent conjugated protein to be distributed in a...

The ability to excite instabilities in free fluid surfaces via acoustic excitation is well known, even to the point of atomization. Surprisingly, atomization phenomena exist at frequencies up to 1 GHz, because peak piezoelectrically-driven vibration velocities remain remarkably constant at about 1 m/s regardless of the excitation frequency if one makes use of different materials and vibration m...

A temporal stability analysis was carried out to model the atomization of a swirling viscous non-Newtonian annular liquid sheet emanating from an air-blast atomizer subject to inner and outer inviscid swirling air streams. The dimensionless dispersion equation that governs the instability of a viscous non-Newtonian annular liquid sheet under swirling air streams was obtained. Numerical solution...

The aim of this work is to show how adaptive mesh refinement and Lagrangian tracking can be integrated to enable high-fidelity computations of jet atomization and dispersion for industrially relevant configurations. In its present form, the Coupled Level Set and Volume of Fluid (CLSVOF) method for multiphase flow calculations is embedded in a dynamic, block-structured Adaptive Mesh Refinement (...