Ghrelin has been found to be associated with anti-inflammatory effects, inhibition of atherosclerotic plaque formation, and plaque stability in the cardiovascular system. We investigated whether ghrelin affected atherosclerotic plaque and inflammation found in atherosclerosis. We crossed ghrelin receptor knock out mice (growth hormone secretagogue receptor (GHSR)-/-) and low-density lipoprotein...

atherosclerosis has serious role in coronary arteries disease,so it is important to establish effective strategies for prevention or even treatment of atherosclerosis. adiponectin, as one of the most abundant adipokines, has insulin sensitivity, anti-inflammatory and anti-atherogenic properties. disturbed adiponectin actions through its receptor, (adipor1 and adipor2) may be involved in atheros...

This article reviews aspects of the molecular pathology of cholesteryl ester accumulation in atherosclerotic lesions. 1. Transcytosis of lipoproteins through cultured endothelial monolayer. 2. Transformation to foam cell from macrophage. 3. Cholesteryl ester deposition in the extracellular space of atherosclerotic lesions. We also discuss the development and use of novel monoclonal antibodies r...

results no correlation between as and history of rt, rt-to-follow-up time interval, laterality of bc, framingham’s 10-year risk score or traditional cad risk factors were detected. increase in cacs related to the senile atherosclerotic process was shown (p < 0.001). conclusions no difference between cacs was noted between bc patients with a history of 3d-crt and the non-bc women without a histo...

Acute coronary syndrome (ACS) is the most severe form of ischemic heart disease. Although it caused by atherosclerotic plaque thrombosis or nonatherosclerotic causes, its pathophysiological mechanism ACS not fully understood, and concept constantly updated developed. At present, main mechanisms include rupture, erosion, calcified nodules (CN) non-atherosclerotic causes such as vasospasm myocard...

Background and Purpose: There is substantial clinical, pathological, and experimental evidence that hypertension aggravates atherosclerosis of the extracranial vessels. The present study assesses the effects of hypertension on the development of cerebral atherosclerosis in nonhuman primates fed an atherogenic diet. Methods: The extent and severity of cerebral atherosclerosis were evaluated morp...

BACKGROUND Apolipoprotein (apo) A-I and apoA-I-mimetic peptides showed promise to prevent atherosclerosis development. Using a bypassed vein graft model in apoE-null mice, we evaluated the effects of oral or intraperitoneal administration of an apoA-I-mimetic peptide on evolving atherosclerotic lesions in the vein graft and compared such effects on the established atherosclerotic lesions in aor...