The anoxemia theory proposes that an imbalance between the demand for, and supply of, oxygen in the arterial wall is a key factor in the development of atherosclerosis. There is now substantial evidence that there are regions within the atherosclerotic plaque in which profound hypoxia exists; this may fundamentally change the function, metabolism and responses of many of the cell types found wi...

The most prevalent form of heart disease is coronary artery [CAD], which currently one the leading causes death in world and predicted to remain that way for next 20 years. Atherosclerosis, genetic predisposition, environment lifestyle are main risk factors CAD. Paraoxonase1 [PON1] a glycoprotein enzyme associated with high-density lipoprotein [HDL] particles blood. It can prevent lipid oxidati...