A natural serum autoantibody specific for the Thy-1 glycoprotein (anti-Thy-1 autoantibody [ATA]) is produced by B-1 cells that are positively selected by self-antigen. Here, using ATA micro kappa transgenic mice we show that cells with this B cell receptor are negatively selected during bone marrow (BM) development. In a Thy-1 null environment, BM ATA B cells progress to a normal follicular sta...

OBJECTIVE This study was conducted to validate the Advanced Test of Attention (ATA) of the visual attention version of Japanese children with attention deficit/hyperactivity disorder (ADHD) and to evaluate the efficacy of methylphenidate (OROS-MPH) and atomoxetine medications. METHODS To assess pharmacotherapy efficacy, the visual version of ATA was administered to 42 children with ADHD. Resu...

Delta9-tetrahydrocannabinol in doses of 0.5, 1.0, 2.0 and 4.0 mg/kg was administered to rats under normal (1 ATA) and increased (3, 5 and 7 times normal) atmospheric pressure. Behavior was maintained by a food-reinforced differential-reinforcemnet-of-low-rate (DRL) schedule. Dose-dependent decrements in performance was observed at the 1 ATA conditions, in which response rates increased and the ...

For models similar to.those used in econometric work, under suitable regularity conditions, the bootstrap is shown to give asymptotically valid approximations to the distribution of errors in coefficient estimates. Running head. Bootstrapping linear models I would like to thank David Brillinger, Edwin Kuh and Thomas Rothenberg for their help.

BACKGROUND The American Thyroid Association (ATA) publishes evidence-based guidelines for the treatment of papillary thyroid carcinoma (PTC). We sought to identify factors associated with receiving treatment compliant with the 2006 ATA guidelines for advanced-stage PTC. METHODS The 2006 ATA guideline compliance was examined in patients with stage III and IV PTC extrapolated from Surveillance,...

Two stratigraphic sections (Kuh-e-Rahmat and Kuh-e-Sabz) of Upper Cretaceous strata in the Interior Fars region (SW of Iran) were selected. Lower Cretaceous succession of Kuh-e-Rahmat was consisted of Dariyan, Kazhdumi Sarvak and Ilam Formations. The lower contact of the Sarvak Formation with Kazhdumi Formation is described as a transitional type whereas the upper contact of Sarvak Formation wa...

BACKGROUND Hepatitis C virus (HCV) NS5B is an essential component of the viral replication machinery and an important target for antiviral intervention. Aurintricarboxylic acid (ATA), a broad-spectrum antiviral agent, was evaluated and characterized for its anti-NS5B activity in vitro and in HCV replicon cells. METHODS Recombinant NS5B, HCV replicase and Huh-7 cells harbouring the subgenomic ...

BACKGROUND Atrial tachyarrhythmias (ATa) can recur after continuous circular lesions (CCLs) around the ipsilateral pulmonary veins (PVs) in patients with atrial fibrillation (AF). This study characterizes the electrophysiological findings in patients with and without ATa after complete PV isolation. METHODS AND RESULTS Twenty-nine of 100 patients had recurrent ATa after complete PV isolation ...

Prostatic hyperplasia can be induced in both intact and castrated dogs and in intact cynomolgus monkeys by the administration of androgenic steroids. Estrogenic steroids potentiate this effect in dogs. These changes also can be induced by androstenedione, which increases androgen and estrogen levels. Atamestane (ATA; 1-methyl-3,17-dione-androsta-1,4-diene), a potent aromatase inhibitor, inhibit...