1School of Material Science, JAPAN Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi city, Ishikawa 923-1292, Japan 2Biotechnology Industrialization Center, National Institute of Advanced Industrial Science and Technology (AIST), c/o Katayanagi Advanced Research Laboratories, Tokyo University of Technology, 1404-1 Katakura, Hachioji, Tokyo 192-0982, Japan 3Biomedical Research Ins...

The formation of mixed self-assembled monolayers (SAMs) from novel biotinylated alkylthiols (BAT) and diluent triethyleneglycol (TEG) alkylthiols on gold has been accomplished using aqueous solvents. We compare the effects of aqueous and ethanolic solvents on the binding performance of mixed SAMs and the integrity of monolayers formed. We use cyclic voltammetry (CV) and fluorescence microscopy ...

The safety argument manager, SAM, is a tool to support the process of developing safety cases [1]. In SAM a safety case is expressed b y a g o al structure and associated solutions. Each solution is expressed in Toulmin argument form. Fault trees can be c on-structed and attached t o a g o al. We have constructed the tool SAM, and investigated how these three dier-ent notations can be used in d...

The thermal behavior of alkyltrichlorosilane (CH3(CH2)n-1SiCl3) based self-assembled monolayers on the oxidized Si(100) surface has been examined under ultrahigh vacuum conditions for n ) 4, 8, and 18. Using high-resolution electron energy loss spectroscopy and contact angle analysis, it is found that the monolayers are stable in vacuum up to about 740 K independent of chain length. Above 740 K...

The concept of commensurability of intraassembly planes is developed and its importance in the formation of stable two-dimensional molecular assemblies is discussed. It is argued that it is not enough to examine the matching of cross-sectional areas of different molecular parts (&). Thus, it is important to consider the crystallographic mismatch of intraassembly atomic planes when designing mol...

Progressive sequence model refinement by means of iterative searches is an effective technique for high sensitivity database searches and is currently employed in popular tools such as PSI-BLAST and SAM. Recently, a novel alignment algorithm has been proposed that offers features expected to improve the sensitivity of such iterative approaches, specifically a well-characterized theory of its st...

Application to self-assembled monolayer junctions Jonatan A. Sierra-Suarez, Shubhaditya Majumdar, Alan J. H. McGaughey, Jonathan A. Malen, and C. Fred Higgs III Department of Electrical and Computer Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, USA Department of Mechanical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pen...

Organized molecular assemblies have been one of the intensely pursued areas of contemporary chemistry. Among the various methodologies used to make organized monolayer structures, self-assembled monolayers (SAMs) have been attractive to many materials chemists owing to the simplicity of the preparative method and high stability. Advances in various techniques and their application in the study ...

Self-assembled monolayers (SAMs) formed on the adsorption of longchain alkanethiols to the surface of gold or alkylsilanes to hydroxylated surfaces are well-ordered organic surfaces that permit control over the properties of the interface at the molecular scale. The abililty to present molecules, peptides, and proteins at the interface make SAMs especially useful for fundamental studies of prot...

The orientation of the biological molecule immobilized on a solid surface has been critical in development of various applications. In this study, orientation of antibody was retained by protecting the antigen-binding site of the antibody prior to immobilization to -functionalized mixed self-assembled monolayer (SAM) of 12-mercaptododecanoic acid and 1-heptanethiol. More importantly, the numbe...