Whether isavuconazole, an extended-spectrum triazole, possesses synergistic activity in combination therapy with echinocandins or amphotericin B for the treatment of invasive molds infections has not been studied. Our in vitro combination studies showed that isavuconazole and micafungin are synergistically active against Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, and Cunnin...

Invasive aspergillosis typically afflicts immunocompromised patients, whereas pulmonary aspergilloma is a recognized complication of pre-existing cavitary lung disease in immunocompetent hosts. In both cases, the most prevalent pathogens are Aspergillus fumigatus and Aspergillus flavus. We describe a case of fatal hemoptysis from invasive Aspergillus niger infection in the setting of bullous lu...

A síntese, a caracterização espectroscópica e os resultados biológicos de novas séries de 2-(4-piridil)-1,2,3,4-tetrahidroquinolinas e seus precursores, -N-aril-N-[1-(4-piridil)but-3-enil] aminas, são descritos. Foi encontrado que ambos, precursores substituídos g-piridil e os produtos finais, as tetrahidroquinolinas, demonstraram excelentes atividades antifúngicas contra Aspergillus fumigatus,...

Chronic pulmonary aspergillosis is broad term encompassing chronic cavitary, chronic fibrosing pulmonary aspergillosis and aspergilloma. All affect patients with structural lung diseases and many have subtle genetic immune defects. Almost all cases are caused by Aspergillus fumigatus. Here we report a patient with an aspergilloma which had Aspergillus flavus recovered from a surgical specimen a...

Susceptibility testing of 27 Aspergillus reference strains belonging to five species was performed using the microdilution broth method with yeast nitrogen broth and RPMI-1640. Similar results were found using the two media. The strains of Aspergillus fumigatus (n = 8) and Aspergillus niger (n = 4) had MICs of amphotericin B in the range 0.125-0.5 mg/L. In contrast, nine out of 13 strains of As...

Aspergillus species frequently colonize lower respiratory tracts and lungs with localized underlying conditions (healed tuberculous cavity, cystic fibrosis, bronchiectasis, etc.) even in subjects without systemic predisposing factors. We investigated the in vitro effects of culture filtrates of Aspergillus species and sputum sols from patients with pulmonary aspergillosis on ciliary beat freque...

Antimicrobial activity of 25, 50, 75 and 100% alcohol extract of Piper nigrum (Black Pepper), Psidium guajava (Guava), Amomum cardamom (Cardamom) and Cynogen dactylon (Bermuda grass) has been evaluated against Pseudomonas lundensis, Bacillus cereus, Aspergillus niger and Aspergillus flavus. Psidium guajava extract showed excellent antimicrobial activity against all the test organisms. In 25% co...

This study investigated the fungicidal activity of selective serotonin reuptake inhibitors (SSRIs) against clinical isolates of Aspergillus fumigatus (n = 11), Aspergillus flavus (n = 9), Aspergillus terreus (n = 10) and Candida parapsilosis (ATCC 22019). The common drugs fluoxetine, seroxate, sertraline, paroxetine and reboxetine were applied in a broth microdilution test. In addition, we exam...

A total of seventeen species belonging to thirteen genera of fungi were isolated from soil samples collected from diverse part of city Bareilly during November 2012 to March 2013 at three intervals. The mycoflora were isolated on Yeast powder soluble starch (YpSs) agar added with antibacterial substances streptomycin. Identification and characterization of the mycoflora were made with the help ...

The aim of this study was to determine the incidence of Aspergillus infections among the patients attending at tertiary care hospital and Hospital environment in Navi Mumbai, India, from January 2014 to December 2014. Total 1785 samples were included in this study for prevalence of Aspergillus species. Out of which 251(14.06%) were positive for Aspergillus infection. Species wise distribution o...