Aspergillus is a ubiquitous fungus and can cause many levels of disease severity. Chronic necrotizing aspergillosis is a rare disease and few cases have been reported in Korea. We experienced a case of pleural aspergillosis that was treated successfully with medical and surgical interventions. The 52-year-old man who was diagnosed with chronic necrotizing pulmonary aspergillosis underwent surgi...

Background and Purpose: Chronic granulomatous disease (CGD) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This disorder results in recurrent life-threatening bacterial and fungal infections. Aspergillus species are the most common fungal infections in these patients. Case Report: Herein, we present a case of fungal infection in a girl wi...

Aspergillosis involving central nervous system (CNS) is known to occur frequently in the immunocompromised individual owing to increased invasive feature of the disease and decreased host defense capacity(1, 2). The common pathway of CNS aspergillosis is hematogenous dissemination usually from lung or continuous extension from adjacent structures such as sinonasal cavity (3, 4). Therefore, the ...

Communications to the Editor 3 Burnie JP. Antigen detection in invasive aspergillosis. J Immunol Methods 1991; 143:187-95 4 Van Cutsenss J, Meulemans L, Van Gerven F, Stynsen D. Detection of circulating gahactomannan by Pastorex Aspergillus in experimental invasive aspergillosis. Mycoses 1990; 33:61-9 5 Hashiguchi K, Wada H, Yamada 0, Yawata Y, Yoshida K, Okimoto N, et al. A case of chronic mye...

Aspergillosis of the central nervous system is a rare disease, especially if the patient's immune system is not compromised. The authors report three cases of cerebral aspergillosis in the immunocompetent state: a rhinocerebral form in a diabetic patient, a direct extension from chronic Aspergillus otitis media, and a postoperative Aspergillus brain abscess after brain tumor surgery. In spite o...

in this study, 60 female, new zealand white rabbits were chosen and divided into 3 groups . the animals in group 1&2 were immunosuppressed with dexamethazone and cyclosporin a (cya) respectively. the animals in group 3 (control animals) were not immunosuppressed. in each group, half of the rabbits were infected intratracheally and the other half were infected intravenously with 4 conidia of asp...

Advancements in early diagnosis and the introduction of effective agents have improved the rates of response of aspergillosis to primary antifungal therapy. These changes allow the subsequent continuation of cytotoxic chemotherapy and/or performance of hematopoietic stem cell transplantation in an increasing number of patients with hematological malignancies. These developments have increased i...

Patients with chronic granulomatous disease (CGD) have the highest life-time incidence of invasive aspergillosis and despite the availability of antifungal prophylaxis, infections by Aspergillus species remain the single most common infectious cause of death in CGD. Recent developments in curative treatment options, such as haematopoietic stem cell transplantation, will change the prevalence of...

Aspergillosis is primarily a pulmonary disease so that renal aspergillosis is usually secondary to hematogenous spread from lungs. Primary renal aspergillosis, though a rare entity, is still seen in immuno-compromised individuals. Renal aspergillosis may lead to formation of focal abscesses, fungal bezoars and may cause ureteric obstruction. Treatment involves stabilization of patient and remov...

Invasive aspergillosis has been mainly reported among immunocompromised patients during prolonged periods of neutropenia. Recently, however, non-neutropenic patients in the ICU population have shown an increasing risk profile for aspergillosis. Associations with chronic obstructive pulmonary disease and corticosteroid therapy have been frequently documented in this cohort. Difficulties in achie...