BACKGROUND Serum paraoxonase 1 (PON1) is an oxidant-sensitive enzyme associated with high-density lipoprotein (HDL) that inhibits the atherogenic oxidation of low-density lipoprotein (LDL). In haemodialysis patients, production of reactive oxygen species, such as hypochlorous acid (HOCl) and hydrogen peroxide, is increased and serum PON1 arylesterase is abnormally low. We have examined the effe...

results administration of dse significantly increased serum paraoxonase and arylesterase activities in treated hypercholesterolemic groups compared to untreated ones. there was a significant difference in the taoc of serum between the normal diet and hypercholesterolemic groups. however, dse did not change the taoc in hypercholesterolemic groups significantly. conclusions dse increases serum pa...

The scope of this study was to determine the eff ect of gemfibrozil, l-carnitine and their combination on paraoxonase/arylesterase activity, oxidative/ anti-oxidative parameters and hepatosteatosis in rabbits on fat-rich diet. The study involved 35 New Zealand albino white rabbits. Animals were equally divided into 5 groups (n=7); group I: control (standard diet), group II: rabbits received onl...

In the α/β hydrolases superfamily, extra module modulated enzymatic activity, substrate specificity, and stability. The functional role of N-terminal extensional long α-helix (Ala2-Glu29, designated as NEL-helix) acting in arylesterase LggEst from Lacticaseibacillus rhamnosus GG had been systemically investigated by deletion mutagenesis, biochemical characterization, biophysical methods. NEL-he...

Human serum paraoxonase (PON) associated with high density lipoprotein (HDL) , has been postulated to have a role in protecting low-density lipoprotein (LDL) against oxidative damage, which has led to the proposal that PON is an anti-atherogenic and anti-inflammatory enzyme. It has genetic polymorphism at the 191 (R ->Q) and two alloenzymes A and B and three phenotypes A, B, and AB. We exa...

INTRODUCTION The aim of this study was to evaluate the serum paraoxonase (PON), arylesterase activities, lipid hydroperoxide (LOOH), sulfhydryl (-SH), and ceruloplasmin (Cp) levels, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) in adults with obstructive sleep apnea syndrome (OSAS) and to determine whether these oxidant and antioxidant levels can b...