Surely the essential feature is the presence of a significant degree of mitral stenosis -that is to say, enough to raise left atrial pressure under various conditions such as exercise, emotion, pregnancy, or tachycardia from any cause. Operation for removal of clot is not an accepted procedure apart from valvotomy. The statement that valvotomy is indicated "provided the valve is suitable for it...

Making Friends is about nursing student Max, medical student Jalisa and a rather grumpy retired man called Arthur. Arthur disapproves of the gardening practices of two young medical students who have the allotment next to his, which was previously kept by Arthur’s recently deceased friend. Arthur has lost his wife through dementia and is finding it difficult to cope with his losses and his arth...

Oliver Smithies Though some 25 years have passed, I can still recall the comfortable predictability of arriving at the lab on a weekend morning and finding Oliver Smithies at work, perhaps at his lab bench setting up a restriction digest in a 5 mL tube or in his office poring over a manuscript. Throughout most of Oliver’s scientific career, one could expect to find him in the lab most evenings ...

?Effraenatam?, the brain-child of Pope Sixtus V [7], was released as a papal bull in the year 1588. Papal bulls are formal declarations issued by the pope of the Roman Catholic Church [8] and are named for their authenticating leaden seals (bullas). This particular document became famous for its official forbiddance of all procured abortions. ?Effraenatam,? meaning ?without restraint,? is often...

Much body image research has been directed toward the study of males (H. G. Pope, K. A. Phillips, & R. Olivardia, 2000). However, little attention has been devoted to consideration of which methods yield the most accurate measurement of this population. Based on numerous social psychological studies indicating the salience of a muscular appearance (e.g., H. G. Pope, R. Olivardia, A. Gruber, & J...

It is painful to start writing an article destined to be an Obituary for a dear friend and a great scientist. To describe Joshua Lederberg as a " polymath " would be an enormous understatement. He made seminal contributions to the fields of microbiology and molecular biology and also to artificial intelligence, organic chemistry, exobiology, and many other disciplines. Joshua Lederberg was born...

The UDP-glucuronosyltransferase (UGT) enzymes are critical for regulating nutrients, hormones, and endobiotics, as well as for detoxifying xenobiotics. Human and murine fetuses are known to express glucuronidation enzymes, but there are currently no data prior to implantation. Here we addressed this gap in knowledge and tested whether Ugt enzymes are already present in preimplantationstage embr...

Dorsal root ganglion stimulation approval by the Food and Drug Administration: advice on evolving the process Timothy R. Deer & Jason E. Pope To cite this article: Timothy R. Deer & Jason E. Pope (2016) Dorsal root ganglion stimulation approval by the Food and Drug Administration: advice on evolving the process, Expert Review of Neurotherapeutics, 16:10, 1123-1125, DOI: 10.1080/14737175.2016.12...

I HIS important address to the First International Congress on the Histopathology of the Nervous System, Pope Pius XII considered the three reasons frequently alleged as a justification for experimentation on human beings. The first of these, the advancement of science, he admitted to be valid within properly determined limits. Speaking of the second alleged reason, the good of the patient, the...