ICDs prevent SCD in patients at high risk for ventricular arrhythmias, but conventional systems carry a of transvenous (TV) lead-related complications. The novel extravascular ICD (EV ICD) may reduce some these complications, while offering ATP, pause prevention pacing, and device similar size projected battery longevity as TV ICD, by placing lead substernally. EV Pivotal study demonstrated saf...

In pulmonary arterial hypertension (PAH), 7% to 30% of patients experience chest pain during exercise1,2 and up 40% them may present left ventricular ischemia caused by extrinsic main coronary artery (LMCA) compression a dilated (PA).2 Because LMCA stenting provide good outcome in this situation,2-4 percutaneous intervention (PCI) is increasingly performed alleviate symptoms, avoid arrythmias, ...

Abstract Background The exercise has well-documented health benefits on cardiovascular disease, and the use of mobile (mHealth) may promote physical activity to reduce risk. Objective present study aimed investigate compliance dose pattern through wearables mHealth in subjects with cardiac arrhythmia a real-world setting. Method photoplethysmography (PPG)-algorithms detect ectopic AF have been ...

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Mitral annular disjunction (MAD) was first described more than 3 decades ago as an abnormal atrial displacement the hinge point mitral valve away from ventricular myocardium. MAD associated with arrythmias and sudden cardiac death, yet some studies suggested that presence can be potentially normal physiological functi...

The effect of drugs and ions upon the normal heart and upon isolated myocardium has been thoroughly investigated and adequately documented. Increased interest in the application of these substances in a manner which approaches the abnormal clinical situation-that is, following coronary artery occlusion and in various arrythmias-has been demonstrated during the past few years. The stimulus for t...

Direct exposure of cardiomyocytes to ethanol causes cardiac damage such as cardiac arrythmias and apoptotic cell death. Cardiomyocytes are connected to each other through intercalated disks (ID), which are composed of a gap junction (GJ), adherens junction, and desmosome. Changes in the content as well as the subcellular localization of connexin43 (Cx43), the main component of the cardiac GJ, a...

paediatric cardiac arrythmias commonly occur in the absence of structural heart disease, and are classified according to their cardiac site of origin. although a detailed history and examination are invaluable, a correct diagnosis cannot be made unless the eCG is analysed, taking into account features specific to this age group. a 24-hour eCG recording may also be helpful. as many of these cond...