Carbon dioxide (CO2 ) represents the most abundant and accessible carbon source on Earth. Thus the ability to transform CO2 into valuable commodity chemicals through the construction of C-C bonds is an invaluable strategy. Carboxylic acids and derivatives, the main products obtained by carboxylation of carbon nucleophiles by reaction of CO2 , have wide application in pharmaceuticals and advance...

Esterification of several carboxylic acids with supercritical alcohols such as 1-propanol, 1butanol, 1-octanol, isoamylalcohol, ethanol, methanol, and subcritical benzyl alcohol without using any catalyst was studied. A variety of esters were synthesized very effectively using supercritical alcohols as solvent and reagent. Moderate to excellent yields were obtained depending on the nature of th...

Antioxidants play an important role in inhibiting and scavenging radicals, thus providing protection to humans against infections and degenerative diseases. The present article focuses on the synthesis and antioxidant activity studies of a variety of 2-aryl thiazolidine -4-carboxylic acids. A series of twenty fully characterized 2-aryl thiazolidine-4-carboxylic acids have been synthesized by nu...

An efficient and practical protocol for palladium-catalyzed decarboxylative arylation of imidazo[1,2-a]pyridine-3-carboxylic acids with aryl chlorides has been developed. Note that the reaction could proceed smoothly without an additive in aqueous medium under an ambient atmosphere, and the addition of H2O could effectively promote the decarboxylative arylation. Particularly noteworthy is that ...

Quinoline and naphthalene-based fluororeceptors 1 and 2 have been designed and synthesized for detection of hydroxy carboxylic acids in less polar solvents. The receptor 1 shows monomer emission quenching followed by excimer emission upon hydrogen bond-mediated complexation of carboxylic acids. The excimer emission distinguishes aromatic dicarboxylic acids from aliphatic dicarboxylic acids and ...

We present our initial results on the use of supercritical carbon dioxide as both a reactant and as a reaction medium to photo-chemically produce carboxylic acids from polycyclic aromatic hydrocarbons via radical anion intermediates. In the present work, we have found that photolysis of anthracene in supercritical carbon dioxide produces up to 57% yield of 9,10-dihydroanthracene-9-carboxylic ac...

The cocrystallization landscape of benzamide and urea interacting with aliphatic and aromatic carboxylic acids was studied both experimentally and theoretically. Ten new cocrystals of benzamide were synthesized using an oriented samples approach via a fast dropped evaporation technique. Information about types of known bi-component cocrystals augmented with knowledge of simple binary eutectic m...

AIM The parent of xGraptoveria, Graptopetalum paraguayense, is used in Chinese folk medicine for alleviating hepatic disorders, detumescence and detoxication, lowering of blood pressure, inhibition of cancer cells, exerting diuretic effects, relieving pain and infections. No data are available regarding its anti-conjunctivitis effect. The aim of this preliminary study is to test the anti-conjun...

The aliphatic carboxylic group was efficiently reduced to the methyl group by HSiEt(3) in the presence of catalytic amounts of B(C(6)F(5))(3). To the best of our knowledge, this is the first example of a direct exhaustive reduction of aliphatic carboxylic function. Aliphatic aldehydes, acyl chlorides, anhydrides, and esters also underwent complete reduction under similar reaction conditions. Ar...

A very simple and convenient reaction for 1,3-diketone preparation from carboxylic acids and aromatic ketones in TFAA/TfOH system is described. When the β-phenylpropionic acids were used as starting materials, they initially gave 1-indanones and then underwent further acylation with the formation of 2-(β-phenylpropionyl)-1-indanones as the main reaction products. In addition, the application of...