Focal adhesions (FAs) are large multi-protein complexes that act as transmembrane links between the extracellular matrix and the actin cytoskeleton. Recently, FAs were extensively characterized, yet the molecular mechanisms underlying their mechanical and signalling functions remain unresolved. To address this question, we isolated protein complexes containing different FA components, from chic...

Received ; accepted – 2 – ABSTRACT Using simultaneous observations of the MDI and EIT instruments on board the SoHO spacecraft, we determined in flight the plate scale of the EIT. We found a value of 2.629 ± 0.001 arc seconds per pixel, in fair agreement with the 2.627 ± 0.001 arc seconds per pixel value deduced from recent laboratory measurements of the focal length, and much higher by 7σ than...

Recent studies have reinforced the view that the lateral hypothalamic area (LHA) regulates food intake and body weight. We identified leptin-sensitive neurons in the arcuate nucleus of the hypothalamus (Arc) that innervate the LHA using retrograde tracing with leptin administration. We found that retrogradely labeled cells in the Arc contained neuropeptide Y (NPY) mRNA or proopiomelanocortin (P...

We establish mutual translations between the classes of 1safe timed-arc Petri nets (and its extension with testing arcs) and networks of timed automata (and its subclass where every clock used in the guard has to be reset). The presented translations are very tight (up to isomorphism of labelled transition systems with time). This provides a convenient characterization from the theoretical poin...

The Shuttle Radar Topography Mission (SRTM) Digital Terrain Elevation Data (DTED) are used with the consensus view that it has a minimum vertical accuracy of 16 m absolute error at 90% confidence (Root Mean Square Error (RMSE) of 9.73 m) world-wide. However, vertical accuracy of the data decreases with increase in slope and elevation due to presence of large outliers and voids. Therefore, studi...

Introduction. A framework for information science based on time is proposed, derived from an exploratory, ethnographic study of information in the hobby of gourmet cooking. Method. Participant obseration of the social world of the hobby, plus twenty semi-structured interviews with hobby cooks, followed by a photographic inventory of their household culinary information collections. Analysis. Da...