BACKGROUND Interactions of free radicals from ionizing radiation with DNA can induce DNA damage and lead to mutagenesis and carsinogenesis. With respect to radiation damage to human, it is important to protect humans from side effects induced by ionizing radiation. In the present study, the effects of arbutin were investigated by using the micronucleus test for anti-clastogenic activity, to cal...

background: the mechanism of hypoglycemic and hypolipidemic activities of pyrus biossieriana buhse leaf extract (pbble) and its phytochemical component arbutin, have not been well determined. the present study was performed to understand the hypoglycemic activity mechanisms of pbble and arbutin more clearly.methods: in vitro enzymatic carbohydrate digestion with pbble and arbutin was assessed u...

The cellobiose catabolic system of Escherichia coli K12 is being used to study the role of cryptic genes in evolution of new functions. Escherichia coli does not use beta-glucoside sugars; however, mutations in several loci can activate the cryptic bgl operon and permit growth on the beta-glucoside sugars arbutin and salicin. Such Bgl+ mutants do not use cellobiose, which is the most common bet...

BACKGROUND The aim of this study was to explore the estrogenic effects of the extracts from Chinese yam and its effective compounds. METHODS The activity of the yam was investigated by the uterine weight gain of mice and a proliferation assay of breast cancer cell lines (MCF-7 cell); the estrogenic activity was comprehensively evaluated by a serum pharmacology experiment. The levels of estrad...

background: interactions of free radicals from ionizing radiation with dna can induce dna damage and lead to mutagenesis and carsinogenesis. with respect to radiation damage to human, it is important to protect humans from side effects induced by ionizing radiation. in the present study, the effects of arbutin were investigated by using the micronucleus test for anti-clastogenic activity, to ca...

Background: Interactions of free radicals from ionizing radiation with DNA can induce DNA damage and lead to mutagenesis and carsinogenesis. With respect to radiation damage to human, it is important to protect humans from side effects induced by ionizing radiation.In the present study, the effects of arbutin were investigated by using the micronucleus test for anti-clastogenic activity, to cal...

Dunalianosides A-I (1-9), esters of arbutin and related phenolic glucosides, were isolated from the buds of Vaccinium dunalianum Wight (Ericaceae) together with 20 known compounds, and their structures were established on the basis of 1- and 2D NMR spectroscopic evidence. Dunalianosides F-H were dimers of p-hydroxyphenyl 6-O-trans-caffeoyl-beta-D-glucopyranoside (10). The latter was obtained in...