Fleet, James C., and Richard J. Wood. Specific 1,25(OH)2D3-mediated regulation of transcellular calcium transport in Caco-2 cells. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G958–G964, 1999.—Calcium transport in the apical-to-basolateral (A-to-B) or B-to-A direction was examined in cells treated with 10 nM 1,25-dihydroxyvitamin D3 [1,25(OH)2D3, calcitriol] for up to 72 h. Net A-to-B...

Robertson, J. Gray, David A. Belford, and F. John Ballard. Clearance of IGFs and insulin from wounds: effect of IGF-binding protein interactions. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E663–E671, 1999.—We have examined the role binding proteins have in regulating the clearance of exogenous growth factors from wounds. Hunt-Schilling chambers were subcutaneously implanted in rats, and the c...

Reed, Jacquelyn A., Machiko Ikegami, Eli R. Cianciolo, Wei Lu, Patricia S. Cho, William Hull, Alan H. Jobe, and JeffreyA. Whitsett. Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice. Am. J. Physiol. 276 (Lung Cell. Mol. Physiol. 20): L556–L563, 1999.—Surfactant proteins and phospholipids accumulate in the alveolar spaces and lung tissues of mice deficient in...

Brito, M. N., N. A. Brito, S. R. C. Brito, M. A. F. Moura, N. H. Kawashita, I. C. Kettelhut, and R. H. Migliorini. Brown adipose tissue triacylglycerol synthesis in rats adapted to a high-protein, carbohydrate-free diet. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1003–R1009, 1999.—Adaptation of rats to a high-protein, carbohydratefree (HP) diet induced a marked reduction o...

Nevière, R. R., M. L. Pitt-Hyde, R. D. Piper, W. J. Sibbald, and R. F. Potter. Microvascular perfusion deficits are not a prerequisite for mucosal injury in septic rats. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G933–G940, 1999.—Our major objective was to investigate whether injury to the mucosa of the small intestine occurred in a normotensive model of sepsis and whether such inju...

BACKGROUND Delayed diagnosis and treatment of newborn infection adversely impact outcomes. Clinical laboratory parameters have aimed to obtain the most correct and prompt diagnosis and treatment of this disease. This study simultaneously observed changes over time in APR as well as proinflammatory cytokines and anti-proinflammatory cytokines and aims to clarify usefulness of APR scores. METHO...

Two classes of genes are used for breeding rust resistant wheat. The first class, called R (for resistance) genes, are pathogen race specific in their action, effective at all plant growth stages and probably mostly encode immune receptors of the nucleotide binding leucine rich repeat (NB-LRR) class. The second class is called adult plant resistance genes (APR) because resistance is usually fun...

CONTEXT Solubility limitation of BCS class II drugs pose challenges to in vitro release. OBJECTIVE To investigate the miscibility of Aprepitant (APR) and Soluplus(®) (SOL) for hot melt extrusion (HME) viability and improved in vitro release of APR. METHODS Solubility parameters of APR and SOL from group contribution methods were evaluated. Heat-cool-heat differential scanning calorimetry (D...

The objective of the present study was to analyze the effect of a mixture of medicinal plants [Angelica gigas Nakai, Panax ginseng and Rhus verniciflua Stokes (APR)] on lipopolysaccharide (LPS)-induced inflammatory responses in the murine macrophage cell line RAW264.7. Cells were treated with APR and LPS at various concentrations and indicated times. WST assay, trypan blue assay and quantificat...