نتایج جستجو برای: apolipoprotein e

تعداد نتایج: 1029260  

2006
Melanie S. Burkhardt Jonathan K. Foster Roger M. Clarnette S. A. Paul Chubb David G. Bruce Peter D. Drummond Ralph N. Martins B. Yeap

Journal: :Neuron 2014
Takahisa Kanekiyo Huaxi Xu Guojun Bu

Among the three human apolipoprotein E (apoE) isoforms, apoE4 increases the risk of Alzheimer's disease (AD). While transporting cholesterol is a primary function, apoE also regulates amyloid-β (Aβ) metabolism, aggregation, and deposition. Although earlier work suggests that different affinities of apoE isoforms to Aβ might account for their effects on Aβ clearance, recent studies indicate that...

Journal: :Arteriosclerosis, Thrombosis, and Vascular Biology 2006

Journal: :Journal of the International Neuropsychological Society : JINS 2017
Claire Lancaster Naji Tabet Jennifer Rusted

OBJECTIVES The apolipoprotein E (APOE) ε4 allele is an established risk factor for dementia, yet this genetic variant is associated with a mixed cognitive profile across the lifespan. This study undertakes both a systematic and meta-analytic review of research investigating APOE-related differences in cognition in mid-adulthood, when detrimental effects of the allele may first be detectable. ...

Journal: :Journal of Alzheimer's disease : JAD 2014
Wasim Khan Vincent Giampietro Cedric Ginestet Flavio Dell'Acqua David Bouls Steven Newhouse Richard Dobson Tobias Banaschewski Gareth J Barker Arun L W Bokde Christian Büchel Patricia Conrod Herta Flor Vincent Frouin Hugh Garavan Penny Gowland Anreas Heinz Bernd Ittermann Hervé Lemaître Frauke Nees Tomas Paus Zdenka Pausova Marcella Rietschel Michael N Smolka Andreas Ströhle Jean Gallinat Eric Westman Gunther Schumann Simon Lovestone Andrew Simmons

Alleles of the apolipoprotein E (ApoE) gene are known to modulate the genetic risk for developing late-onset Alzheimer's disease (AD) and have been associated with hippocampal volume differences in AD. However, the effect of these alleles on hippocampal volume in younger subjects has yet to be clearly established. Using a large cohort of more than 1,400 adolescents, this study found no hippocam...

Journal: :iranian journal of pharmaceutical research 0
nafiseh khandouzi department of nutrition & biochemistry, school of nutritional sciences & dietetics, tehran university of medical sciences farzad shidfar department of nutrition & biochemistry, school of nutritional sciences & dietetics, tehran university of medical sciences asadollah rajab iranian diabetes association tayebeh rahideh department of nutrition & biochemistry, school of nutritional sciences & dietetics, tehran university of medical sciences payam hosseini razi hospital-psychiatry mohsen mir taheri razi hospital-psychiatry

diabetes mellitus is the most common endocrine disorder, causes many complications such as micro- and macro-vascular diseases. anti-diabetic, hypolipidemic and anti-oxidative properties of ginger have been noticed in several researches. the present study was conducted to investigate the effects of ginger on fasting blood sugar, hemoglobin a1c, apolipoprotein b, apolipoprotein a-i, and malondial...

Akbari MT Asgari N Babamohammadi GH Zare Sh

Background: The role of apolipoprotien E polymorphisms do not diagnostic correctly in recurrent pregnancy loss etiology but Apo E has been shown to play an important role in lipid metabolism in pregnancy. We evaluated these polymorphisms in Iranian women with unexplained recurrent pregnancy loss. Materials and Methods: 5 ml Blood were sampling from 81 women with a history of two or more consecu...

2001
Charles F. Sing Kathy L. Klos Sharon L. R. Kardia Robert E. Ferrell Stephen T. Turner Eric Boerwinkle Sharon L.R. Kardia

Results of genome-wide linkage analyses to identify chromosomal regions that influence interindividual variation in plasma lipid and apolipoprotein levels in the Rochester, Minn, population are reported. Analyses were conducted for total cholesterol (total-C), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), apolipoprotein A-I, apolipoprotein A-II, apolipoprotein B, apolipopro...

2005
Remy Couderc Florence Mahieux Sophie Bailleul Gilles Fenelon

coronary artery disease. We investigated the putative role of apolipoprotein E phenotypes in cerebral infarction. Methods: The apolipoprotein E phenotypes of 69 patients (mean±SD age, 72±+11 years) who had suffered completed stroke or a transient ischemic attack and 68 sexand age-matched control subjects free of cerebrovascular disease were determined by isoelectric focusing. The relative frequ...

2003
John R. Lynch Wen Tang Haichen Wang Michael P. Vitek Ellen R. Bennett Patrick Sullivan David S. Warner Daniel T. Laskowitz

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