AIM Glucagon-like peptide-1 can reduce both postprandial plasma glucose (PG) and chylomicron (CM) levels in patients with type 2 diabetes. However, there have been no reports regarding the relationship between the postprandial metabolism of PG and CM. METHODS Patients with type 2 diabetes who were admitted for glycemic control were randomized to insulin alone (Ins; n=16) or insulin plus vilda...

Postprandial hyperglycemia is well established as a major risk factor for prediabetes and type 2 diabetes. However, postprandial hyperlipidemia, no definitive criteria exist, fasting values of lipids lipoproteins had limited efficacy estimating lipidemia. In the present study, we performed fat-ingestion test aimed to propose indices lipoprotein metabolism. Methods: Healthy young Japanese women ...

Aim To elucidate the impact of liraglutide on kinetics apolipoprotein (apo)B48- and apoB100-containing triglyceride-rich lipoproteins in subjects with type 2 diabetes (T2D) after a single fat-rich meal. Materials Methods Subjects T2D were included study to investigate postprandial apoB48 apoB100 metabolism before 16 weeks l.8 mg/day (n = 14) or placebo 4). Stable isotope tracer compartmental mo...

Changes of lipoprotein secretion and composition in response to CCl4 treatment were studied in monolayer cultures of rat primary hepatocytes. (1) CCl4 decreased secretion of very low density lipoproteins (VLDL) by about 85%, while high density lipoprotein (HDL) secretion was less affected (about 40%). The effect was concentration-dependent. (2) CCl4 significantly inhibited secretion of VLDL- an...

Serum lipoproteins (LP) are increasingly being recognized as dual purpose molecules that contribute to both cholesterol homeostasis and host innate defense. In fact, very low LP levels are associated with increased risk of bacterial infection in critically ill patients. In this respect, we reported that apolipoprotein B100 (apoB100), the 4536 amino acid structural protein of very low density li...

Objective—The risk of atherosclerosis in the setting of chylomicronemia has been a topic of debate. In this study, we examined susceptibility to atherosclerosis in Gpihbp1-deficient mice (Gpihbp1 / ), which manifest severe chylomicronemia as a result of defective lipolysis. Methods and Results—Gpihbp1 / mice on a chow diet have plasma triglyceride and cholesterol levels of 2812 209 and 319 27 m...

Editing of apolipoprotein (apo)-B100 mRNA to yield apo-B48 is a specific and developmentally regulated step in enterocytes of mammals. However, the functional significance of this step is not known. Since mice containing only apo-B100 have not been documented to exhibit any difference in intestinal fat absorption from wild-type mice, the evolutionary advantage of apoB mRNA editing has been ques...

BACKGROUND Visceral obesity and insulin resistance are associated with a postprandial accumulation of atherogenic chylomicron remnants that is difficult to modulate with lipid-lowering therapies. Dietary fish oil and exercise are cardioprotective interventions that can significantly modify the metabolism of TAG-rich lipoproteins. In this study, we investigated whether chronic exercise and fish ...