Six cases of red cell aplasia occurring in patients with myelodysplastic syndromes (MDS) showed a diversity of clinical course and prognosis. In some patients red cell aplasia may have represented an evolution of MDS while in others autoimmune destruction of erythoblasts may have been the mechanism. A proliferative phase is seen in many of these patients, the clinical importance of which is unc...

Large granular lymphocyte leukemia-associated pure red cell aplasia accounts for a significant portion of secondary pure red cell aplasia cases. However, because of its rarity, long-term responses and relapse rates after immunosuppressive therapy are largely unknown. We conducted a nationwide survey in Japan and collected 185 evaluable patients. Fourteen patients with large granular lymphocyte ...

Background: Germ cell aplasia is a type of azoospermia characterized by hormonal abnormalities as well as histopathological features. Objective: To assess hormonal and histological aspects of germ cell aplasia among infertile men in Gaza Strip. Materials and methods: A total of 375 infertile men visiting the Specialized Medical Centers in Gaza strip were subjected for testicular biopsy. Out of ...

INTRODUCTION The complete absence of the chiasm (chiasmal aplasia) is a rare clinical condition. Hypoplasia of the optic nerve and congenital nystagmus are almost invariably associated characteristics. Microphthalmos or anophthalmos are common features in chiasmal aplasia, while central nervous system abnormalities are less frequent. Esophageal atresia can be isolated or syndromic. In syndromic...

1. Good RA. Agammaglobulinemia: a provocative experiment of nature. Bull Univ Minn Hosp Min Med Found 1954; 26:1-19. 2. Levinson AI, Hoxie JA, Kornstein MJ, Zembryki D, Matthews DM, Schreiber AD. Absence of the OKT4 epitope on blood T cells and thymus cells in a patient with thymoma, hypogammaglobulinemia, and red blood cell aplasia. J Allergy Clin Immunol 1985; 76: 433-9. 3. Oshimi K. Granular...

BACKGROUND Thrombopoietin (TPO), the major hormone controlling platelet production, has been measured in thrombocytopenias with discordant results. The aim of our work was to assess the value of the TPO assay for differential diagnosis of thrombocytopenias in a large cohort of patients classified according to the results of their platelet isotopic study. METHODS We measured TPO (R&D Systems) ...

BACKGROUND AND PURPOSE High-resolution MR imaging enables direct imaging of the ocular motor nerves. The aim of this study was to assess the various causes of congenital or developmental neuropathic strabismus by using high-resolution MR imaging. MATERIALS AND METHODS High-resolution MR imaging was performed to evaluate the ocular motor nerves (CNIII, CNIV, CNVI) in 247 consecutive patients w...

although the most common hematological disturbance in thymoma is pure red cell aplasia, pancytopenia is a very rare paraneoplastic syndrome in this disorder. we only found one case in literature reviews. we report a 36 year old female with an anterior mediastinal mass and severe pancytopenia. with a mediastinotomy incision, biopsy of the tumor was obtained. the report of the pathologist was thy...

Defects in the establishment and development of cruciate ligaments are one main causes instability knee joint congenital longitudinal defects lower limbs. This pathology occurs with a frequency 0.017 per 1000 newborns. The absence leads to change shape articular surfaces joint, is formed due hypoplasia femoral condyles, intercondylar fossa femur, elevation tibia. Purpose - study stressed-deform...