OBJECTIVES Recent studies have investigated the occurrence of human cytomegalovirus and Epstein-Barr Virus in samples from apical periodontitis lesions and a role in the pathogenesis of this disease has been suggested. Because genotype distribution and seroprevalence of EBV and HCMV differ among populations, it is important to determine the presence of these viruses in endodontic periapical les...

‘Prognosis’ is the forecast of the course of a disease. In the context of apical periodontitis, therefore, this term applies to both the time course and chances of healing. Over the past 80 years, an extensive volume of studies has been amassed that focuses on the prognosis of apical periodontitis after endodontic therapy. Cumulatively, the authors of these studies have recorded, grouped, and a...

The dental pulp space can become infected due to a breach in the surrounding hard tissues. This leads to inflammation of the pulp (pulpitis), soft tissue breakdown, and finally to bone loss around the root apex (apical periodontitis). The succession of the molecular events leading to apical periodontitis is currently not known. The main inflammatory mediator associated with neutrophil chemotaxi...

AIM To study the prevalence of apical periodontitis in smoker and nonsmoker patients. METHODOLOGY In a cross-sectional study, the records of 180 subjects, 109 smokers and 71 nonsmokers, were examined. All participants underwent a full-mouth radiographic survey incorporating 14 periapical radiographs. The periapical region of all teeth, excluding third molars, was examined. Periapical status w...

Apical periodontitis is a group of inflammatory diseases caused by microorganisms (mainly bacteria) infecting the necrotic root canal system. The pathogenesis of different types of apical periodontitis and even the same type in different individuals is unlikely to follow a stereotyped fashion with regard to the involved bacterial mediators. Disease pathogenesis is rather complex and involves a ...

OBJECTIVES This review article discusses the host response in apical periodontitis with the main focus on cytokines, produced under this pathological condition and contributing to the degradation of periradicular tissues. The pace of research in this field has greatly accelerated in the last decade. Here we provide an analysis of studies published in this area during this period. MATERIAL AND...

Endodontic treatment approaches aim to achieve proper and prevention of apical periodontitis enhance the oral health status prognosis affected teeth. However, many complications can develop secondary endodontic treatment. The management post-treatment might be challenging clinicians, is usually lower than that primary periodontitis. Therefore, identifying potential etiology intervening against ...