quadricuspid aortic valve (qav) is an uncommon congenital anomaly which was an incidental finding during surgery or autopsy in the past. we present the case of a 44-year-old woman with moderately severe aortic regurgitation due to unequal cusp size qav diagnosed via transesophageal echocardiography. due to echocardiographic imaging improvement, the diagnosis of qav is now easier and earlier tha...

Since the first cardiac valve replacement in the early sixth decade of the last century, the search continued for ideal cardiac valve substitute with proven structural durability over a period of 10 to 20 years, central flow orifice without transvalvular gradient, absence of host reactivity deleterious to valve function, non-thrombogenecity without the use of anti-coagulant, resistance to infec...

Marfan syndrome (MFS) is a hereditary disorder of the connective tissue that causes life-threatening aortic aneurysm, which initiates at the aortic root and can progress into the ascending portion. However, analysis of ascending aorta reactivity in animal models of MFS has remained elusive. Epidemiologic evidence suggests that although MFS is equally prevalent in men and women, men are at a hig...

Abstract Background To investigate the function of transient receptor potential melastatin 2 (TRPM2) in vascular reactivity induced by 5-hydroxytryptamine (5-HT) aorta during development atherosclerosis mice. Methods Forty mice were randomly divided into 4 groups: C57BL/6J on normal diet (C57 + ND), high-fat HFD), apolipoprotein E gene knockout (ApoE−/−) ND (ApoE−/− and ApoE−/− HFD HFD). They f...

Background: Diabetes is an important risk factor for cardiovascular events. Endothelial dysfunction is the main reason cause of disability and death in diabetic patients and death. The present study investigates the effects of metformin and glibenclamide on vasoconstrictive and vasodilative responses in the diabetic rat aorta. Methods: Rats were divided into four experimental groups (con...

stanford type a acute aortic dissection (aad) is a very rare complication, with potentially lethal consequences in pregnancy. in fact, pregnancy has been regularly associated with the possibility of aortic. dissection in almost half of young women. herein, we present the case of a 38-year-old woman in her 37th week of pregnancy. the patient’s medical history was indicative of g4l2ab1(4 gestaiti...