The benzimidazole compound omeprazole, used widely for the treatment of peptic ulcer disease, inhibits the growth of Leishmania donovani, the causative agent of visceral leishmaniasis. Promastigotes cultured at acidic pH and amastigotes within infected macrophages are reduced 90% or more with 150 microM omeprazole. Antiparasitic action of the drug is due to its inhibition of the P-type K(+),H(+...

Background: The fruit juice of Syzygium alternifolium is used to cure stomach ache and ulcers, while fruit pulp and alcoholic extract of seeds posses anti-diabetic properties. The leaves of plants are claimed for anti-ulcer properties by folklore medicine. Objective: To investigate the antiulcer activity of Ethanolic extract of Syzygium alternifolium (EESA) leaves by Pylorus ligation (Shay rat ...

the antiulcer effects of different tricyclic antidepressants (trimipramine, doxepin, imipramine, and amitriptyline) in comparison with those of cimetidine, pirenzepine and omeprazole were investigated in male rats with acute gastric ulcer. acute gastric ulcer was induced by oral administration of o. 6n hcl solution, 1 ml/rat. pretreatment of animals with doxepin, trimipramine, amitriptyline, im...