teucrium polium l. (lamiaceae) is used in the traditional medicine of iran for the treatment of disorders of the gastrointestinal tract. the essential oil from the aerial parts of t polium was assessed for antispasmodic activity and compared with the effect of atropine and dicyclomine. acetylcholine and kc i were used for induction of contraction on rat isolated ileum. teucrium polium essential...

A new series of N-substituted bis-(tetrahydropapaverine) ring systems have been synthesised in expectation of better antispasmodic activity in comparison with papaverine. The synthesis of the targeted heterocycles is described along with a discussion of their structure activity relationship. The general synthetic methods of bis-(tetrahydropapaverine) analogues involve tetrahydropapaverine, vari...

A series of novel N-substituted 2-methyl imidazole derivatives have been synthesized, and their in vitro antispasmodic activity was assessed on contractions of isolated guinea pig ileum, induced by acetylcholine (5× 10M to 1× 10M), and compared with the effect of atropine. All the prototypes were synthesized and confirmed by their FTIR, HNMR, MASS and elemental spectral data. Antispasmodic acti...

The antispasmodic and spasmolytic effects of methanolic extract of seeds of Garcinia kola Heckel were studied on smooth muscle preparations in vitro. The influence of the extract on rat duodenum, jejunum and ileum was investigated using acetylcholine and barium chloride as agonists. The extract exhibited dose-dependent antispasmodic effects on contractions induced by acetylcholine, and dose-dep...

genus peucedanum belongs to the subfamily of apioideae (umbelliferae family) and is reported to have many medicinal properties. several spiecis of peucedum reported to have antispasmodic activity. p eucedanum pastinacifolium species grows in iran. however, so far there is no report on its antispasmodic activity. the objective of this research was to investigate antispasmodic activities of p. pa...

Alcoholic and water extracts of many medicinal plants are commonly used in German folk medicine and other countries as antispasmodics. However, so far no data on dose relationships or comparisons of the antispasmodic effects with reference substances have been available for most of these plant extracts. Using acetylcholine as the stimulating agent, the antispasmodic effect of preparations ...

Objective: Several studies have shown the antispasmodic activity of Matricariarecutita without detailing the underlying mechanism(s). The present study was designed to determine whether the antispasmodic mechanisms of M. recutita extract mediated via histaminergic/cholinergic receptors, Ca2+channels, activation of PKA2 and NO release in isolated rabbit jejunum. Methods and Materials: The concen...

objectives: mentha longifolia l. (lamiaceae) is an annual herb that is used in the iranian traditional medicine for treating stomach and intestinal disorders. the purpose of this study was to determine the protective effect of m. longifolia on experimental diarrhea in a rat model. materials and methods: the antidiarrheal activity of essential oil of m. longifolia (20-80 mg/kg) was investigated ...