The objective of this work has been the co-precipitation of the coating material Ethyl Cellulose (EC) and two natural extracts (IDOKI SCF Technologies), R1 and P1, using the Supercritical Antisolvent (SAS) precipitation technique with supercritical carbon dioxide (SC-CO2), in order to obtain active microparticles. EC is a hydrophobic material widely used for controlled delivery systems, sustain...

Coaxial flow injection and mixing of solvent antisolvent flows prevent contact the lipid solution with microchannel walls enable stable continuous precipitation monodisperse nanoparticles in order 150 nm below.

One of the most important environmental concerns for the polymer industry is to produce new products with near-zero residual monomer content. A new process based on supercritical CO2 has been successfully tested for the extraction of the residual monomer and the simultaneous micronization of the polymer. The process has been tested on a pilot-scale plant. The reduction of methyl methacrylate (M...

A series of copper-zinc acetate and zincian georgeite precursors have been produced by supercritical CO2 antisolvent (SAS) precipitation as precursors to Cu/ZnO catalysts for the water gas shift (WGS) reaction. The amorphous materials were prepared by varying the water/ethanol volumetric ratio in the initial metal acetate solutions. Water addition promoted georgeite formation at the expense of ...

Although ultrasound is employed increasingly as an adjunct to biomechanical preparation in clinical endodontics for adult teeth, there have been no previous investigation of this technique for primary teeth. This investigation studied the efficacy of ultrasonication compared with mechanical cleaning in primary root canals using a novel radiometric method. The results indicated that in multiple-...

Gentamicin (GEN) is an aminoglycoside antibiotic with a potent antibacterial activity against a wide variety of bacteria. However, its poor cellular penetration limits its use in the treatment of infections caused by intracellular pathogens. One potential strategy to overcome this problem is the use of particulate carriers that can target the intracellular sites of infection. In this study GEN ...

BACKGROUND Silibinin has gained in importance in the past few decades as a hepatoprotector and is used widely as oral therapy for toxic liver damage, liver cirrhosis, and chronic inflammatory liver diseases, as well as for the treatment of different types of cancers. Unfortunately, it has low aqueous solubility and inadequate dissolution, which results in low oral bioavailability. MATERIALS A...

size reduction of high energy materials such as 1, 3, 5, 7-tetranitro- 1, 3, 5, 7-tetraaza cyclooctane (hmx) has considerable influences on improving their explosive characteristics. in this study, nanosized hmx par­ticles were produced using ultrasonically reprecipitation method by applying water as a safe and accessible antisolvent instead of unsafe conventional methods. sem photographs revea...