normal 0 false false false en-us x-none ar-sa background: cardiovascular diseases, cardiovascular risk factors, and mortality due to these situations are more frequently encountered in schizophrenic patients when compared with the general population. the mean platelet volume (mpv) is a surrogate biomarker of the platelet activity and an useful prognostic test in cardiometabolic diseases. the ai...

BACKGROUND The introduction of second-generation antipsychotic drugs during the 1990s is widely believed to have adversely affected mortality of patients with schizophrenia. Our aim was to establish the long-term contribution of antipsychotic drugs to mortality in such patients. METHODS Nationwide registers in Finland were used to compare the cause-specific mortality in 66 881 patients versus...

Parkinsonism and tardive dyskinesia can coexist in patients taking antipsychotic drugs. Persistence of both parkinsonism and tardive dyskinesia during a two year follow up period after discontinuation of antipsychotic drugs is reported. Etiological significance of antipsychotic treatment is discussed.

BACKGROUND Users of typical antipsychotic drugs have an increased risk of serious ventricular arrhythmias and sudden cardiac death. However, less is known regarding the cardiac safety of the atypical antipsychotic drugs, which have largely replaced the older agents in clinical practice. METHODS We calculated the adjusted incidence of sudden cardiac death among current users of antipsychotic d...

Objective: To choose typical or atypical antipsychotic drugs for treatment of schizophrenic patients in a psychiatric hospital. Method: A standard method was used; this method considers 4 main evaluation criteria and 4 secondary criteria. The typical antipsychotic drug, perphenazine, was compared with the atypical antipsychotic drugs (olanzapine, quetiapine, risperidone, and ziprasidone). The m...

Effectiveness of currently available antipsychotic medications is far from satisfactory with many patients showing incomplete therapeutic response even after many trials with different antipsychotic drugs. Hence, there is an ongoing interest in searching for pharmacological mechanisms, which could potentiate therapeutic response to antipsychotic drugs and/or reduce its typical side effects. The...

Antipsychotic drugs are particularly interesting in pharmacogenetic studies as they are associated with a large interindividual variability in terms of response and side effects and, therefore, frequently need to be discontinued, requiring switches to other antipsychotics. Any information that allows the prediction of outcome to a given antipsychotic in a particular patient will, therefore, be ...

OBJECTIVE To determine the factors associated with high-dose antipsychotic prescribing for psychiatric patients in Hong Kong. DESIGN Retrospective cross-sectional study. SETTING Psychiatric in-patients and out-patients in the New Territories West Cluster, Hong Kong. PATIENTS A total of 1129 in-patients and 7520 out-patients who received antipsychotic medications on the study date. MAIN ...

The present study deals with the functional interaction of antipsychotic drugs and NMDA receptors. We show that both the conventional antipsychotic drug haloperidol and the atypical antipsychotic drug clozapine mediate gene expression via intracellular regulation of NMDA receptors, albeit to different extents. Data obtained in primary striatal culture demonstrate that the intraneuronal signal t...