introduction: stroke is one of the most important reasons of death. hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide. the ischemia-reperfusion causes hypoxia, hypoglycemia and incomplete repel of metabolic waste products and leads to accumulation of free radicals triggering neuronal death. the a1 adenosine receptoras an endogenous l...

background: renal ischemia reperfusion injury may occur in a variety of clinical situations, following a transient drop in total or regional blood flow to the kidney. this study was performed to investigate the protective effects of different antioxidants such as vitamin c, vitamin e, hydrocortisone and combination of these agents against experimental renal ischemia-reperfusion injury. method:...

objectives: curcumin has anti-inflammatory and antioxidative properties. the objective of this study was to investigate the therapeutic effects of curcumin on functional disturbances, oxidative stress, and leukocyte infiltration induced by renal ischemia/reperfusion (i/r). materials and methods: animals were randomly divided into 9 groups. the groups with 24-h reperfusion consisted of sham-24h,...

background: this study was conducted to reveal that whether i.v. injection of oleuropein, the most potent polyphenolic antioxidant in olive leaf, has any effect on the magnitude of reperfusion arrhythmia in anesthetized rats or not. methods: eighty male wistar rats were divided into 8 groups of 10 each: groups 1 and 5 were assigned as the prophylactic and treatment control groups, groups 2 and ...

nitric oxide (no) is implicated as an important mediator of, or intermediary in, inflammation, immunity and neurotransmission. in the kidney, no is involved in haemodynamic regulation, control of vascular tone and tubular function. formation of oxygen-derived free radicals (ofr) have been documented in renal ischaemia- reperfusion before. in this study , we investigated the significance of no f...

objective(s):to investigate the effects of local mild hypothermia on the expression of fas, fasl and mmp-3 after cerebral ischemia-reperfusion in rats. materials and methods:male wistar rats were divided into sham-operated group (sham), normothermia group (nt), and hypothermia group (ht). mcao/r model was established by longa’s method, and reperfusion was allowed after 2 hr occlusion. mild hypo...

An ischemia-reperfusion (I/R) injury of small intestine is a serious and common condition that result the blockage superior mesenteric artery (SMA) because significant clinical problems. This study evaluated effect Mesna on systemic induced by ischemia/reperfusion (IR) in also liver, kidney lung as remote organs. Forty Wistar albino rats were randomly divided into four groups: control, ischemia...

Abstract Background and Aims Previous studies in chronic kidney disease (CKD) showed that vascular dysfunction different circulatory beds is progressively deteriorating with CKD severity. This study evaluated muscle oxygenation microvascular reactivity at rest, during an occlusion-reperfusion maneuver, exercise patients pre-dialysis versus controls, as well between stages Method Continuous meas...

The purpose of this study is to evaluate the preventive effects Urtica dioica (UD) on muscle ischemia/reperfusion (I/R) injury. A total 27 male Wistar rats were divided into three groups as control group (1), I/R + saline (2), and I/R+UD (3). Group 1 did not receive any treatment. 2 was administered a 2mL/kg (1mL/kg before ischemia mL/kg after reperfusion), 3 given 2mL UD 1mL/kg reperfusion) Sa...

Objective Improvement in ex vivo lung perfusion protocols could increase the number of donors available for transplantation and protect lungs from primary graft dysfunction. We hypothesize that perfusate adsorption during reconditions allograft to ischemia–reperfusion injury after transplantation. Methods Donor pig were preserved 24 hours at 4°C, followed by 6 according Toronto protocol. The wa...