Multicentric Reticulohistiocytosis (MRH) is a rare histiocytic disorder that primarily involves the skin and joints but can affect multiple visceral organs. A female patient presented a characteristic papulonodular skin eruption and polyarthritis with positive Antinuclear Antibody (ANA), and skin biopsy findings demonstrated classic features of MRH. The patient’s clinical manifestations were in...

The association of human T-lymphotropic virus type I (HTLV-I) with autoimmune disorders was investigated on the basis of prevalence of antinuclear antibody (ANA), rheumatoid factor and anti-thyroglobulin antibody as well as immunoglobulin (Ig) serum level (IgG, IgA, and IgM). The subjects, all atomic bomb survivors, were 59 HTLV-I-seropositive people without HTLV-I-associated myelopathy or adul...

Autoimmune pancreatitis (AIP) was first used to describe cases of pancreatitis with narrowing of the pancreatic duct, enlargement of the pancreas, hyper-γ-globulinaemia, and antinuclear antibody (ANA) positivity serologically. The main differential diagnosis, is pancreatic cancer, which can be ruled out through radiological, serological, and histological investigations. The targets of ANA in pa...

AIMS/BACKGROUND Anterior uveitis associated with juvenile chronic arthritis concerns two different clinical entities: firstly, antinuclear antibody (ANA) positive patients who have a chronic anterior uveitis with severe complications and often a poor visual prognosis; secondly, usually HLA-B27 positive children, predominantly boys, with unilateral recurrent anterior uveitis. Three patients are ...

background: systemic lupus erythematosus (sle) has various presentations in children. hematologic abnormalities is common in childhood onset of sle, however, isolated thrombocytopenia is relatively rare. thus, we present a child with isolated thrombocytopenia as a rare presentation of sle. case presentation: a 12-year-old boy with chief complaints of loss of appetite, weight loss, decreased pla...

A 24 year old woman was diagnosed with systemic lupus erythematosis (SLE) based on a few months’ history of a photosensitive skin rash, predominantly on her face, arthralgia involving both hands and wrists, a positive antinuclear antibody (ANA) test and a raised antinative double stranded DNA antibody binding level. She was treated with oral hydroxychloroquine 400 mg daily and short courses of ...

Methods Patients who received montelukast for CIU between 2008-2011 (4-year period) were retrospectively identified from clinic letters. Clinical features of duration of urticaria, medication use, autoimmunity and laboratory investigations that included basopenia and mean platelet volume on full blood count, complement levels, specific IgE, autoimmune serology [antinuclear antibody (ANA), thyro...

A 60-year-old woman was admitted to our hospital because of anorexia and vomiting. Hematology revealed elevated levels of hepatobiliary enzymes and positive results for antinuclear antibody (ANA) and antimitochondrial (AMA) M2 antibody. Immunoglobulin (Ig) G and IgM levels were extremely elevated, 3,379 mg/dl and 4,250 mg/dl, respectively. A diagnosis of primary biliary cirrhosis and autoimmune...

Some patients with rheumatoid arthritis (RA) as well as those with other collagen diseases are positive for antinuclear antibody (ANA). We investigated the frequency of positivity for ANA in 104 patients with RA and evaluated the clinical features and laboratory data in the ANA-positive and -negative groups. The presence of ANA in sera was studied by indirect immunofluorescence using HEp-2 cell...

Systemic lupus erythematosus (SLE) is a systemic inflammatory disease secondary to an autoimmune response that characterized by the deposition of immune complexes activate complement and cause tissue damage. The American College Rheumatology (ACR, Rheumatology) in 2012 established new diagnostic criteria for SLE, identifying 17 which at least 4 must be met (at one clinical, immunologic) or neph...