When 3acetylpyridine (3-AP) is fed to dogs, large amounts of a normal end-product of nicotinic acid metabolism, N’-methylnicotinamide (NMeN), appear in the urine (1). This finding might be interpreted as evidence that 3-AP, acting as an antivitamin, displaces nicotinamide from its nucleotides or prevents its incorporation therein, or, alternatively, that 3-AP is biologically oxidized to nicotin...

Exotoxin from B. thuringiensis was purified by chromatography and its structure was determined by means of chemical and physical methods. The formula of the substance as given above indicates that the exotoxin possesses between ribose and glucose an unusual ether bond which up to now has not been found in Nature. The study of the mechanism of action of the exotoxin shows that it competes with A...

alpha-Aminoisobutyryl-d-alanine, d-alanyl-alpha-aminoisobutyric acid, and alpha-amino-isobutyryl-alpha-aminoisobutyric acid, proposed as antimetabolites of d-alanyl-d-alanine in bacterial cell wall synthesis, failed to inhibit bacterial growth.

Human cancer cell lines are used as important model systems to study molecular mechanisms associated with tumor growth, hereunder how genomic and biological heterogeneity found in primary tumors affect cellular phenotypes. We reconstructed Genome scale metabolic models (GEMs) for eleven cell lines based on RNA-Seq data and validated the functionality of these models with data from metabolite pr...

Protein-bound polysaccharide K (PSK) is an anticancer agent used for adjuvant therapy against gastric cancer. The aim of this study was to evaluate the effect of PSK on the overall survival of patients with gastric cancer. A total of 254 patients who underwent surgical curative resection were included in this retrospective study. We identified 138 patients who received antimetabolites alone (co...

PURPOSE To report the incidence of recurrence after primary pterygium surgery using either a free conjunctival or limbal-conjunctival autograft without antimetabolites. METHODS One hundred eleven eyes of 90 patients underwent pterygium resection; a free conjunctival autograft was used in 88 surgeries and a free limbal-conjunctival autograft in 24; the latter technique was reserved for dark-sk...