The eight Northeastern (NE) states sharing a significant proportion of malaria cases reported in every year from India. Nowadays, several classes of antimalarial drugs like chloroquine, sulphadoxine-pyrimethamine, combination drugs artemisinin plus sulphadoxine-pyrimethamine etc. are used for treatment of malaria cases. In NE states, several research works are going on at molecular level for ev...

malaria is currently one of the most important causes of mortality in developing countries. high resistance to available antimalarial drugs has been reported frequently, thus it is crucial to focus on the discovery of new antimalarial drugs. artemisinin, an effective antimalarial medication, is isolated from various artemisia species. to identify the artemisia species producing high quantity of...

BACKGROUND The high rate of mortality due to malaria and the worldwide distribution of parasite resistance to the commonly used antimalarial drugs chloroquine and pyrimethamine emphasize the urgent need for the development of new antimalarial drugs. An alternative approach to the long and uncertain process of designing and developing new compounds is to identify among the armamentarium of drugs...

Antimalarial drug resistance has now become a serious global challenge and is the principal reason for the decline in antimalarial drug efficacy. Malaria endemic countries need inexpensive and efficacious drugs. Preserving the life spans of antimalarial drugs is a key part of the strategy for rolling back malaria. Artemisinin-based combinations offer a new and potentially highly effective way t...

OBJECTIVE Malaria is an infectious disease commonplace in tropical countries. For many years, major antimalarial drugs consisted of natural products, but since 1930s these drugs have been largely replaced with a series of synthetic drugs. This article tries to briefly indicate that some plants which previously were used to treat malaria, as a result of deficiencies of synthetic drugs, have revi...

the diastereoisomer of quinine, can also cause this compliAn accurate and promptly-available blood or plasma glucose cation [2]. The 4-aminoquinoline chloroquine is known to concentration may, on its own, be very useful clinically but influence glucose metabolism in ways which could lead to is a limited measure of glucose tolerance in a patient with a low blood glucose concentrations [3, 4], al...

Background: Malaria remains the world’s most devastating human parasitic infection. Our goal was to assess the capacity of increasing concentrations of five antimalarial drugs (Fansidar, Halfan, Quinine, Coartem and Chloroquine phosphate) to elicit the generation of methemoglobin in three human erythrocyte genotypes (Hb AA, Hb AS and Hb SS). Materials and Methods: Spectrophotometric method was ...