OBJECTIVE To investigate whether the use of incretin-based drugs (GLP-1 receptor agonists and dipeptidyl peptidase 4 [DPP4] inhibitors) is associated with acute pancreatitis. RESEARCH DESIGN AND METHODS The study was a nationwide population-based case-control study using medical databases in Denmark. Participants were 12,868 patients with a first-time hospitalization for acute pancreatitis be...

Diabetes mellitus, one of the non-communicable diseases, is still the seriously problem due to leading the causes of death in the developed countries. Therefore it is important to identify novel nutraceuticals or drugs for curing or preventing diabetes because the existing synthetic drugs have several limitations. Traditional medicinal plants and medicinal mushrooms are used in the treatment of...

Chalcones considered as the precursor of flavonoids and isoflavonoids abundantly found in plants, and have also been shown to display a diverse array of pharmacological activities. This review is complementary to earlier reviews and covers more recent report of antimicrobial activity of chalcones as well as its important role as an intermediate for the synthesis of different synthetic molecules...

Pteris vittata L., a fern was evaluated for its alpha amylase inhibitory potential owing to its previously reported antihyperglycemic activity. This Pteridophyte was also assayed for its free radical inhibition ability in ABTS decolourisation assay followed by quantification and HPTLC of polyphenols. The Porcine pancreatic alpha amylase inhibition was studied invitro and compared with standard ...

Polyand multifunctional piperidines isolated from microorganisms and plants are powerful and specific glycosidase inhibitors, and they have the potential to produce a number of kinds of beneficial therapeutic effects such as antihyperglycemic, antiviral and anticancer activity, etc. l) A multifunctional piperidine, siastatin B (1) which was isolated as an inhibitor of neuraminidase by H. Umezaw...

Medicinal plants in genus Lagerstroemia were investigated for phytochemical contents by GC-MS and HPLC with ethanol and hexane extracts and their toxicity MTT and comet assay on human peripheral blood mononuclear cells (PBMCs). γ-Sitosterol is the major component found in all species at 14.70-34.44%. All of the extracts, except for L. speciosa ethanol extract, showed high percentages of cell vi...

The diversity of plants in Armenia is due to the singularity natural environment. However, biochemical activity these has not been studied well. goal was investigate biological activities as well antihyperglycemic properties Rumex obtusifolius L. rabbits with hyperglycemia. According obtained data, R. extracts possessed high antioxidant chemical-based tests. GS/MS analysis its methanol allowed ...

Costus species is a significant restorative and decorative plant used to fix various illnesses. In India 6,000 plants are for traditional herbal medicine. The spicatus commonly known as ‘Spiral ginger’ ‘insulin plant’, wonder drug down blood sugar level hypoglycemic properties. has been found have numerous pharmacological exercises, example, antibacterial, antifungal, anticholineesterase, cance...

Abstract Background Annona species can be found in the subtropical and tropical parts of world. Because their medicinal capabilities highly exotic edible fruits, they are one most important members Annonaceae family. Isoquinolines, pyrimidine-?-carboline alkaloids, lectins, acetogenins, volatile oils among active metabolites this genus, all which have been shown to anti-diabetic antioxidant act...

background: the present work was planned to evaluate the antihyperglycemic, lipid‑lowering, and antioxidant effect of lactobacillus casei and bifidobacterium bifidum in streptozotocin (stz)‑induced diabetic rats. methods: single daily dose of 1 × 107 cfu/ml of l. casei and b. bifidum alone and in combination of both was given to wistar rats orally by gavaging for 28 days. glucose tolerance test...