this paper is the first phytochemical and abts cation radical decolorisation activity, cupric reducing antioxidant capacity, anticholinesterase and dna damage protection effect of endemic verbascum pinetorum (boiss.) o. kuntze. phenolic profile of v. pinetorum were qualified and quantified by uhplc-esi-ms/ms analysis. malic acid (47250.61±2504.28 µg/g) and luteolin (7651.96±527.98 µg/g) were fo...

Activity-directed isolation of the ethyl acetate, methylene chloride and n-hexane fractions of Gloiopeltis furcata resulted in the isolation of 18 compounds. Their structures were elucidated as 2-(3-hydroxy-5-oxotetrahydrofuran-3-yl)acetic acid (1), glutaric acid (2), succinic acid (3), nicotinic acid (4), (E)-4-hydroxyhex-2-enoic acid (5), cholesterol (6), 7-hydroxycholesterol (7), uridine (8)...

Animals pretreated with appropriate closes of anticholinesterase agents develop auricular flutter and fibrillation following injection of acetylcholine or vagal stimulation. Depression of normal sinoauricular nodal function facilitates induction of fibrillation. During fibrillation, additional injections of acetylcholine, or vagal stimulation, increase the rate of fibrillation. Atropine in smal...

Bztients with neurologic diseases who require surgery may present the anesthetist with special challenges related to their pharmocotherapy. It is well established that such therapy may alter these patients' otherwise normal response to anesthesia. There are many classes of drugs utilized and this AANA Journal course addresses the pharmacokinetic pharmacodynamic and anesthetic implications of an...

A 10-month-old American cocker spaniel was evaluated for megaesophagus, aspiration pneumonia, but no appendicular muscle weakness. During hospitalization, weakness of the facial muscles developed, this resolved with anticholinesterase administration. Serum antibodies against acetylcholine receptors were documented, confirming the diagnosis of focal myasthenia gravis. Diagnosis, management, and ...