In the present work, the anticariogenic activities of three pimarane-type diterpenes obtained by fungal biotransformation were investigated. Among these metabolites, ent-8(14),15-pimaradien-19-ol was the most active compound, displaying very promising MIC values (ranging from 1.5 to 4.0 μg mL(-1)) against the main microorganisms responsible for dental caries: Streptococcus salivarius, S. sobrin...

Dental caries is a progressive disease with varying phases of demineralization and remineralization, the scope reversing carious lesion increased if it diagnosed before there surface cavitation. Preventive management strategies are directed towards making enamel more resistant acid dissolution. The preventive protocol has always been fluoride-centric. Repeated application fluoride gives rise to...

OBJECTIVES The aim of this study was to verify the anticariogenic effect of acidulate solutions with low NaF concentration, using pH-cycling model and bovine enamel. MATERIAL AND METHODS Enamel blocks were submitted to the surface microhardness (SMH) test and randomly divided in 12 experimental and one placebo groups. The blocks were submitted to pH cycling for 7 days, with daily applications...

Streptococcus mutans is the leading cause of dental caries worldwide by accumulating a glycogen-like internal polysaccharide (IPS) that contributes to cariogenicity when sugars are in excess. Sodium monofluorophosphate (MFP) is an active anticariogenic compound in toothpastes. Herein, we show that MFP inhibits (with an I0.5 of 1.5 mM) the S. mutans ADP-glucose pyrophosphorylase (EC 2.7.7.27), w...

Food can have a mighty biological, therapeutic and preventive effect, yet its breakdown can provide the perfect setting for tooth decay and its implications, diseases of the periodontium and the oral mucosa. Due to the high incidence of periodontal and hard dental tissues pathologies among adolescents they have been ranked as socially significant diseases. A damaged dental-jaw apparatus may lea...

The caries inhibitory effect of extract from tea which is one of the most popular beverages consumed has been studied both in vitro and in vivo. The exact mechanism by which tea can prevent dental caries is yet not known, but certain theories like bactericidal effects of tea against Streptococcus mutans and prevention of bacterial adherence to teeth have been suggested. The present article desc...

This in vitro study evaluated the antimicrobial activity of extracts obtained from Rheedia brasiliensis fruit (bacupari) and its bioactive compound against Streptococcus mutans. Hexane, ethyl-acetate and ethanolic extracts obtained (concentrations ranging from 6.25 to 800 microg/ml) were tested against S. mutans UA159 through MIC/MBC assays. S. mutans 5-days-old biofilms were treated with the a...

Milk is an important component of a balanced diet and contains numerous valuable constituents. Considerable acclaimed health benefits of milk are related to its proteins, not only for their nutritive value but also for their biological properties. Scientific evidence suggests that anticarcinogenic activities, antihypertensive properties, immune system modulation, and other metabolic features of...

BACKGROUND Streptococcus mutans (ATCC25175) has a profound effect on the incidence of dental decay in the human population. Many studies have been performed to assess the antimicrobial activity of different cements. However, little or no information is available about the antibacterial properties of Type II glass ionomer cement (GIC), Type IX GIC, and AMALGOMER™ ceramic reinforcement (CR). AI...