Antibiotic DE-3936 was isolated from the fermentation broth of a streptomycete No. 9735-1, which is identified as a strain of Streptomyces hygroscopicus. The antibiotic is a hydrophobic compound having the molecular formula of of C44H75O14Na and is active against Gram-positive bacteria, mycobacteria, mycoplasma and protozoa, especially coccidia. Its chemical and biological properties indicate ...

A new antibiotic kazusamycin, was isolated from the culture broth of Streptomyces sp. No. 81-484, which shows antitumor activity against experimental murine tumors. This antibiotic did not possess antibacterial activity against Gram-positive and Gram-negative bacteria, but showed strong cytotoxic activity against HeLa cells in vitro. The chemical and physico-chemical properties of kazusamycin s...

Pamamycin is a new antibiotic isolated from Streptomyces alboniger ATCC 12461. The antibiotic is active in vitro against Gram-positive bacteria, Neurospora, and Mycobacteria. The compound also acts as a streptomycete differentiation effector. It stimulates aerial mycelia formation in the producing organism. The new antibiotic of elemental composition C36H63NO7 is completely different from purom...

The use of antibiotic-loaded cement spacers is an established method in the management of periprosthetic hip and knee joint infections. Despite inconsistencies among published studies, data shows that infection control rates exceed 90% with two-stage exchange arthroplasty. The present work reviews the current literature about antibiotic-loaded cement spacers and concentrates on the indications ...

In the course of screening for antibacterial antibiotics from actinomycetes, a new antibiotic, OM704 A, has been isolated from the culture broth of strain OM-704, a soil isolate identified as Streptomyces sp. This antibiotic was active against Gram-positive bacteria. The present paper deals with the taxonomy of strain OM-704 and the fermentation, isolation and biological and physicochemical pro...

Phagolessin A58, an antibiotic substance active against a number of bacterial viruses, was studied for activity against the seven T phages. Only three of the seven phages-T1, T3, and T7-proved to be sensitive to the antibiotic. The antibiotic caused a direct, apparently irreversible inactivation of free phage particles. A study of the properties of the inactivated phage particles showed that th...